Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)    
Predicted Functional Partners:
NCSTN
Nicastrin.
   
 0.997
PSENEN
Presenilin enhancer, gamma-secretase subunit.
    
 0.997
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
 0.995
PSEN2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
 0.995
APH1A
Aph-1 homolog A, gamma-secretase subunit.
  
  
0.929
NOTCH1
Notch receptor 1.
    
 0.808
NOTCH3
Notch receptor 3.
    
 0.796
NOTCH4
Notch receptor 4.
    
 0.771
NOTCH2
Notch receptor 2.
    
 0.742
SNX31
Sorting nexin 31.
   
  
 0.707
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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