DYRK3 protein (Rhinopithecus roxellana) - STRING interaction network

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Score

DYRK3

Dual specificity tyrosine phosphorylation regulated kinase 3. (588 aa)

Predicted Functional Partners:

DCAF7

0.702

TP53

0.663

ATM

0.619

ENSRROP00000033818

0.488

EEF2

0.457

DCAF1

0.433

EPB42

0.424

LIN52

0.423

CBFB

0.422

UBC

0.412

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	DYRK3	ENSRROP00000031543	ENSRROP00000004635	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.619
ATM	ENSRROP00000033818	ENSRROP00000031543	ENSRROP00000033818	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.914
ATM	TP53	ENSRROP00000031543	ENSRROP00000026843	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.998
ATM	UBC	ENSRROP00000031543	ENSRROP00000018766	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.701
CBFB	DYRK3	ENSRROP00000014727	ENSRROP00000004635	Core-binding factor subunit beta.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.422
DCAF1	DYRK3	ENSRROP00000000441	ENSRROP00000004635	DDB1 and CUL4 associated factor 1.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.433
DCAF7	DYRK3	ENSRROP00000037320	ENSRROP00000004635	DDB1 and CUL4 associated factor 7.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.702
DYRK3	ATM	ENSRROP00000004635	ENSRROP00000031543	Dual specificity tyrosine phosphorylation regulated kinase 3.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.619
DYRK3	CBFB	ENSRROP00000004635	ENSRROP00000014727	Dual specificity tyrosine phosphorylation regulated kinase 3.	Core-binding factor subunit beta.	0.422
DYRK3	DCAF1	ENSRROP00000004635	ENSRROP00000000441	Dual specificity tyrosine phosphorylation regulated kinase 3.	DDB1 and CUL4 associated factor 1.	0.433
DYRK3	DCAF7	ENSRROP00000004635	ENSRROP00000037320	Dual specificity tyrosine phosphorylation regulated kinase 3.	DDB1 and CUL4 associated factor 7.	0.702
DYRK3	EEF2	ENSRROP00000004635	ENSRROP00000004770	Dual specificity tyrosine phosphorylation regulated kinase 3.	Eukaryotic translation elongation factor 2.	0.457
DYRK3	ENSRROP00000033818	ENSRROP00000004635	ENSRROP00000033818	Dual specificity tyrosine phosphorylation regulated kinase 3.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.488
DYRK3	EPB42	ENSRROP00000004635	ENSRROP00000026565	Dual specificity tyrosine phosphorylation regulated kinase 3.	Erythrocyte membrane protein band 4.2.	0.424
DYRK3	LIN52	ENSRROP00000004635	ENSRROP00000029725	Dual specificity tyrosine phosphorylation regulated kinase 3.	Lin-52 DREAM MuvB core complex component.	0.423
DYRK3	TP53	ENSRROP00000004635	ENSRROP00000026843	Dual specificity tyrosine phosphorylation regulated kinase 3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.663
DYRK3	UBC	ENSRROP00000004635	ENSRROP00000018766	Dual specificity tyrosine phosphorylation regulated kinase 3.	Uncharacterized protein.	0.412
EEF2	DYRK3	ENSRROP00000004770	ENSRROP00000004635	Eukaryotic translation elongation factor 2.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.457
EEF2	TP53	ENSRROP00000004770	ENSRROP00000026843	Eukaryotic translation elongation factor 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.419
EEF2	UBC	ENSRROP00000004770	ENSRROP00000018766	Eukaryotic translation elongation factor 2.	Uncharacterized protein.	0.598