node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABRAXAS1 | ANKRD12 | ENSRROP00000010058 | ENSRROP00000009814 | Abraxas 1, BRCA1 A complex subunit. | Ankyrin repeat domain 12. | 0.882 |
ABRAXAS1 | BAP1 | ENSRROP00000010058 | ENSRROP00000033773 | Abraxas 1, BRCA1 A complex subunit. | Ubiquitin carboxyl-terminal hydrolase. | 0.539 |
ABRAXAS1 | BRCA1 | ENSRROP00000010058 | ENSRROP00000033524 | Abraxas 1, BRCA1 A complex subunit. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.994 |
ABRAXAS1 | ENSRROP00000000782 | ENSRROP00000010058 | ENSRROP00000000782 | Abraxas 1, BRCA1 A complex subunit. | Metallophos domain-containing protein. | 0.546 |
ABRAXAS1 | LOC104679892 | ENSRROP00000010058 | ENSRROP00000024307 | Abraxas 1, BRCA1 A complex subunit. | BRCT domain-containing protein. | 0.949 |
ABRAXAS1 | MRE11 | ENSRROP00000010058 | ENSRROP00000034122 | Abraxas 1, BRCA1 A complex subunit. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.546 |
ABRAXAS1 | NBN | ENSRROP00000010058 | ENSRROP00000027235 | Abraxas 1, BRCA1 A complex subunit. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.608 |
ABRAXAS1 | RBBP8 | ENSRROP00000010058 | ENSRROP00000002805 | Abraxas 1, BRCA1 A complex subunit. | RB binding protein 8, endonuclease. | 0.512 |
ANKRD12 | ABRAXAS1 | ENSRROP00000009814 | ENSRROP00000010058 | Ankyrin repeat domain 12. | Abraxas 1, BRCA1 A complex subunit. | 0.882 |
ANKRD12 | BAP1 | ENSRROP00000009814 | ENSRROP00000033773 | Ankyrin repeat domain 12. | Ubiquitin carboxyl-terminal hydrolase. | 0.744 |
ANKRD12 | BRCA1 | ENSRROP00000009814 | ENSRROP00000033524 | Ankyrin repeat domain 12. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.874 |
ANKRD12 | ENSRROP00000000782 | ENSRROP00000009814 | ENSRROP00000000782 | Ankyrin repeat domain 12. | Metallophos domain-containing protein. | 0.746 |
ANKRD12 | LOC104679892 | ENSRROP00000009814 | ENSRROP00000024307 | Ankyrin repeat domain 12. | BRCT domain-containing protein. | 0.874 |
ANKRD12 | MRE11 | ENSRROP00000009814 | ENSRROP00000034122 | Ankyrin repeat domain 12. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.746 |
ANKRD12 | NBN | ENSRROP00000009814 | ENSRROP00000027235 | Ankyrin repeat domain 12. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.838 |
ANKRD12 | RAD51 | ENSRROP00000009814 | ENSRROP00000001279 | Ankyrin repeat domain 12. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.752 |
ANKRD12 | RBBP8 | ENSRROP00000009814 | ENSRROP00000002805 | Ankyrin repeat domain 12. | RB binding protein 8, endonuclease. | 0.907 |
ANKRD12 | TOPBP1 | ENSRROP00000009814 | ENSRROP00000015596 | Ankyrin repeat domain 12. | DNA topoisomerase II binding protein 1. | 0.851 |
BAP1 | ABRAXAS1 | ENSRROP00000033773 | ENSRROP00000010058 | Ubiquitin carboxyl-terminal hydrolase. | Abraxas 1, BRCA1 A complex subunit. | 0.539 |
BAP1 | ANKRD12 | ENSRROP00000033773 | ENSRROP00000009814 | Ubiquitin carboxyl-terminal hydrolase. | Ankyrin repeat domain 12. | 0.744 |