STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (131 aa)    
Predicted Functional Partners:
HCRTR1
Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family.
   
 0.990
HCRTR2
Hypocretin receptor 2; Belongs to the G-protein coupled receptor 1 family.
   
 0.990
PMCH
Pro-melanin concentrating hormone.
   
 
 0.905
ENSRROP00000010170
Uncharacterized protein.
   
 
 0.905
HLA-DQB1
Major histocompatibility complex, class II, DQ beta 1.
    
 
 0.894
HLA-DQA1
Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family.
    
 
 0.848
TRH
Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
     
 0.747
GHRL
Ghrelin and obestatin prepropeptide.
     
 0.736
NPY
Neuropeptide Y.
   
  
 0.708
NTS
Neurotensin.
     
 0.688
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.