node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BN85313040 | BN85313050 | BN85313040 | BN85313050 | ATP-dependent Clp protease (ATP-binding subunit, clpB), fragment 1; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease ATP-binding subunit, fragment 2. | 0.986 |
BN85313040 | clpB | BN85313040 | BN85305390 | ATP-dependent Clp protease (ATP-binding subunit, clpB), fragment 1; Belongs to the ClpA/ClpB family. | Chaperone protein ClpB. | 0.976 |
BN85313040 | dnaJ | BN85313040 | BN85307080 | ATP-dependent Clp protease (ATP-binding subunit, clpB), fragment 1; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.734 |
BN85313040 | dnaK | BN85313040 | BN85307070 | ATP-dependent Clp protease (ATP-binding subunit, clpB), fragment 1; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK (Heat shock 70 kDa protein); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.885 |
BN85313040 | groEL | BN85313040 | BN85316800 | ATP-dependent Clp protease (ATP-binding subunit, clpB), fragment 1; Belongs to the ClpA/ClpB family. | 60 kDa chaperonin (GroEL protein); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.593 |
BN85313040 | groES | BN85313040 | BN85316810 | ATP-dependent Clp protease (ATP-binding subunit, clpB), fragment 1; Belongs to the ClpA/ClpB family. | 10 kDa chaperonin (GroES); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. | 0.591 |
BN85313040 | grpE | BN85313040 | BN85307060 | ATP-dependent Clp protease (ATP-binding subunit, clpB), fragment 1; Belongs to the ClpA/ClpB family. | Protein GrpE (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | 0.671 |
BN85313040 | hrcA | BN85313040 | BN85307050 | ATP-dependent Clp protease (ATP-binding subunit, clpB), fragment 1; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.497 |
BN85313040 | htpG | BN85313040 | BN85314840 | ATP-dependent Clp protease (ATP-binding subunit, clpB), fragment 1; Belongs to the ClpA/ClpB family. | Heat shock protein HtpG; Molecular chaperone. Has ATPase activity. | 0.607 |
BN85313040 | lon | BN85313040 | BN85309170 | ATP-dependent Clp protease (ATP-binding subunit, clpB), fragment 1; Belongs to the ClpA/ClpB family. | Serine protease Lon, ATP-dependent; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.585 |
BN85313050 | BN85313040 | BN85313050 | BN85313040 | ATP-dependent Clp protease ATP-binding subunit, fragment 2. | ATP-dependent Clp protease (ATP-binding subunit, clpB), fragment 1; Belongs to the ClpA/ClpB family. | 0.986 |
BN85313050 | dnaJ | BN85313050 | BN85307080 | ATP-dependent Clp protease ATP-binding subunit, fragment 2. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.734 |
BN85313050 | dnaK | BN85313050 | BN85307070 | ATP-dependent Clp protease ATP-binding subunit, fragment 2. | Chaperone protein DnaK (Heat shock 70 kDa protein); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.885 |
BN85313050 | groEL | BN85313050 | BN85316800 | ATP-dependent Clp protease ATP-binding subunit, fragment 2. | 60 kDa chaperonin (GroEL protein); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.593 |
BN85313050 | groES | BN85313050 | BN85316810 | ATP-dependent Clp protease ATP-binding subunit, fragment 2. | 10 kDa chaperonin (GroES); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. | 0.591 |
BN85313050 | grpE | BN85313050 | BN85307060 | ATP-dependent Clp protease ATP-binding subunit, fragment 2. | Protein GrpE (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | 0.671 |
BN85313050 | hrcA | BN85313050 | BN85307050 | ATP-dependent Clp protease ATP-binding subunit, fragment 2. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.497 |
BN85313050 | htpG | BN85313050 | BN85314840 | ATP-dependent Clp protease ATP-binding subunit, fragment 2. | Heat shock protein HtpG; Molecular chaperone. Has ATPase activity. | 0.607 |
BN85313050 | lon | BN85313050 | BN85309170 | ATP-dependent Clp protease ATP-binding subunit, fragment 2. | Serine protease Lon, ATP-dependent; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.585 |
clpB | BN85313040 | BN85305390 | BN85313040 | Chaperone protein ClpB. | ATP-dependent Clp protease (ATP-binding subunit, clpB), fragment 1; Belongs to the ClpA/ClpB family. | 0.976 |