Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sdaASerine dehydratase, single chain form. (399 aa)    
Predicted Functional Partners:
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.960
cysE
Serine acetyltransferase.
     
 0.927
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.900
BN85308370
Aldo/keto reductase family protein.
     
  0.800
trmA
tRNA (Uracil-5-)-methyltransferase, SAM dependent; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
       0.773
BN85312450
Zn-dependent carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.
       0.773
nifJ
Pyruvate-flavodoxin oxidoreductase.
     
 0.752
mgtE
Mg2+ transporter (MgtE).
       0.561
mgtE-2
Magnesium (Mg2+) transporter; Acts as a magnesium transporter.
       0.561
gcvT
Glycine cleavage system T protein.
  
  
 0.435
Your Current Organism:
Acholeplasma brassicae
NCBI taxonomy Id: 61635
Other names: A. brassicae, ATCC 49388, strain 0502
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