STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
csgACurlin; The major structural subunit of curlin which assemble to form curli which can bind to fibronectin; Derived by automated computational analysis using gene prediction method: Protein Homology. (151 aa)    
Predicted Functional Partners:
csgB
Curlin subunit CsgB; CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.968
ANG92373.1
Curli assembly protein CsgC; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.708
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.607
parE
DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
   
 
 0.607
ANG91645.1
Murein transglycosylase D; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.427
macB
Macrolide ABC transporter permease/ATP-binding protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
     
 0.414
ANG94904.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.403
Your Current Organism:
Lelliottia amnigena
NCBI taxonomy Id: 61646
Other names: ATCC 33072, CCUG 14182, CIP 103169, CUETM 77-118, DSM 4486, Enterobacter amnigenus, Enterobacter amunigenu, Enterobacter amunigenus, L. amnigena, LMG 2784, LMG:2784, NBRC 105700, NCTC 12124
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.