STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
luxS-2S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (151 aa)    
Predicted Functional Partners:
mtnN
5'-methylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/U [...]
 
  
 0.836
AKL15033.1
Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.776
AKL15029.1
Methionine-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.682
AKL15031.1
Methionine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.675
metN-4
Methionine ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
       0.668
AKL15028.1
Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.542
AKL11915.1
Methionine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.504
MetB
Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.497
AKL15034.1
Biotin transporter BioY; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
       0.474
AKL10569.1
Cystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.470
Your Current Organism:
Kluyvera intermedia
NCBI taxonomy Id: 61648
Other names: ATCC 33110, CCUG 14183, CIP 79.27, CUETM 77-130, DSM 4581, Enterobacter intermedium, Enterobacter intermedius, Enterobacter intrermedium, K. intermedia, Kluyvera cochleae, LMG 2785, LMG:2785, NBRC 102594, NCTC 12125, strain Gavini E 86
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