STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
mnmC_2tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the C-terminal section; belongs to the DAO family. (673 aa)    
Predicted Functional Partners:
gcvT_1
Sarcosine oxidase alpha subunit; Belongs to the GcvT family.
  
 
 0.865
fabB
3-oxoacyl-[acyl-carrier-protein] synthase, KASI; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
       0.566
rluA_1
Ribosomal large subunit pseudouridine synthase A.
 
    0.563
smtA
S-adenosylmethionine-dependent methyltransferase; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family.
  
 
 
 0.501
AML57746.1
Sarcosine oxidase delta subunit.
  
 
 0.499
nadE
NAD synthetase / Glutamine amidotransferase chain of NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
  
  
 0.498
thiI
tRNA S(4)U 4-thiouridine synthase (former ThiI); Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
 
   
 0.489
AML57741.1
Malonyl CoA-acyl carrier protein transacylase.
  
  
 0.485
yaaA
UPF0246 protein YaaA; Belongs to the UPF0246 family.
 
     0.476
selU
Selenophosphate-dependent tRNA 2-selenouridine synthase; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
  
   
 0.474
Your Current Organism:
Serratia rubidaea
NCBI taxonomy Id: 61652
Other names: ATCC 27593, CCUG 10981, CCUG 9286, CIP 103234, DSM 4480, LMG 5019, LMG:5019, NBRC 103169, NCTC 12971, S. rubidaea, Serratia marinorubra, Serratia sp. V1E5a
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