node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GCA_000733925_01575 | folD | GCA_000733925_01575 | GCA_000733925_03424 | Unannotated protein. | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.527 |
GCA_000733925_01575 | glyA | GCA_000733925_01575 | GCA_000733925_02811 | Unannotated protein. | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.705 |
GCA_000733925_01575 | purC | GCA_000733925_01575 | GCA_000733925_01636 | Unannotated protein. | Unannotated protein; Belongs to the SAICAR synthetase family. | 0.803 |
GCA_000733925_01575 | purD | GCA_000733925_01575 | GCA_000733925_04542 | Unannotated protein. | Unannotated protein; Belongs to the GARS family. | 0.922 |
GCA_000733925_01575 | purE | GCA_000733925_01575 | GCA_000733925_03550 | Unannotated protein. | Unannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.765 |
GCA_000733925_01575 | purF | GCA_000733925_01575 | GCA_000733925_04176 | Unannotated protein. | Unannotated protein. | 0.972 |
GCA_000733925_01575 | purH | GCA_000733925_01575 | GCA_000733925_03817 | Unannotated protein. | Unannotated protein. | 0.775 |
GCA_000733925_01575 | purL | GCA_000733925_01575 | GCA_000733925_02688 | Unannotated protein. | Unannotated protein; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.985 |
GCA_000733925_01575 | purM | GCA_000733925_01575 | GCA_000733925_03021 | Unannotated protein. | Unannotated protein. | 0.720 |
GCA_000733925_01575 | purN | GCA_000733925_01575 | GCA_000733925_04173 | Unannotated protein. | Unannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.976 |
folD | GCA_000733925_01575 | GCA_000733925_03424 | GCA_000733925_01575 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Unannotated protein. | 0.527 |
folD | glyA | GCA_000733925_03424 | GCA_000733925_02811 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.979 |
folD | purC | GCA_000733925_03424 | GCA_000733925_01636 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Unannotated protein; Belongs to the SAICAR synthetase family. | 0.500 |
folD | purD | GCA_000733925_03424 | GCA_000733925_04542 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Unannotated protein; Belongs to the GARS family. | 0.527 |
folD | purE | GCA_000733925_03424 | GCA_000733925_03550 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Unannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.503 |
folD | purF | GCA_000733925_03424 | GCA_000733925_04176 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Unannotated protein. | 0.574 |
folD | purH | GCA_000733925_03424 | GCA_000733925_03817 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Unannotated protein. | 0.972 |
folD | purL | GCA_000733925_03424 | GCA_000733925_02688 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Unannotated protein; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.852 |
folD | purM | GCA_000733925_03424 | GCA_000733925_03021 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Unannotated protein. | 0.631 |
folD | purN | GCA_000733925_03424 | GCA_000733925_04173 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Unannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.966 |