STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDB43149.1Homocitrate synthase NifV; Belongs to the alpha-IPM synthase/homocitrate synthase family. (379 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
 
 
 0.957
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.944
ilvD
Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.942
SDB05492.1
3-isopropylmalate dehydrogenase.
 
 0.927
SDB51314.1
Branched chain amino acid aminotransferase apoenzyme.
  
 0.891
SDB26103.1
Acetolactate synthase, large subunit.
 
 
 0.888
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.865
SDB03058.1
Para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase.
  
 0.861
SDB57353.1
Pyruvate-ferredoxin/flavodoxin oxidoreductase.
  
 
 0.844
SDB26087.1
Acetolactate synthase, small subunit.
 
 
 0.843
Your Current Organism:
Desulfonatronum thiosulfatophilum
NCBI taxonomy Id: 617002
Other names: D. thiosulfatophilum, DSM 21338, Desulfonatronum sp. AHT30, Desulfonatronum sp. ASO4-2, Desulfonatronum thiosulfatophilum Sorokin et al. 2011, UNIQEM U757, strain ASO4-2
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