Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1960 aa)    
Predicted Functional Partners:
ENSACIP00000019830
Sodium channel, voltage-gated, type I, beta a.
    
 0.967
ENSACIP00000024977
Ig-like domain-containing protein.
    
 0.948
ENSACIP00000013913
Ig-like domain-containing protein.
    
 0.947
ENSACIP00000018905
Sodium channel, voltage-gated, type IV, beta b.
    
 0.912
UNC79
Unc-79 homolog, NALCN channel complex subunit.
   
 0.912
ENSACIP00000019942
Si:ch211-225p5.8.
     
  0.892
ENSACIP00000013881
Sodium channel, voltage-gated, type II, beta.
   
 0.868
ENSACIP00000002336
Sodium channel, voltage-gated, type III, beta.
    
 0.812
ENSACIP00000019551
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
    
 0.780
ENSACIP00000004061
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
    
 0.777
Your Current Organism:
Amphilophus citrinellus
NCBI taxonomy Id: 61819
Other names: A. citrinellus, Archocentrus citrinellum, Cichlasoma citrinellum, Herichthys citrinellus, Heros citrinellus, Midas cichlid, red devil, red devil cichlid
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