Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ENSACIP00000001221COP1 E3 ubiquitin ligase. (688 aa)    
Predicted Functional Partners:
ENSACIP00000020373
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.995
ENSACIP00000015474
DET1 partner of COP1 E3 ubiquitin ligase.
    
 0.994
ENSACIP00000026665
Damage-specific DNA binding protein 1.
    
 0.993
ENSACIP00000016927
Tribbles pseudokinase 3.
    
 
 0.978
ENSACIP00000016064
JunE proto-oncogene, AP-1 transcription factor subunit.
    
 
 0.976
ENSACIP00000011640
Ets variant 1.
    
 
 0.975
ENSACIP00000023052
Ets variant 5a.
    
 
 0.975
ENSACIP00000012470
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.974
ENSACIP00000023242
Serine/threonine kinase 40.
    
 
 0.974
ENSACIP00000005847
Damage-specific DNA binding protein 2.
    
 0.961
Your Current Organism:
Amphilophus citrinellus
NCBI taxonomy Id: 61819
Other names: A. citrinellus, Archocentrus citrinellum, Cichlasoma citrinellum, Herichthys citrinellus, Heros citrinellus, Midas cichlid, red devil, red devil cichlid
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