| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADSSL1 | ASS1 | ENSACIP00000018637 | ENSACIP00000025357 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Argininosuccinate synthase 1. | 0.937 |
| ADSSL1 | ENSACIP00000001356 | ENSACIP00000018637 | ENSACIP00000001356 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | 0.929 |
| ADSSL1 | ENSACIP00000001652 | ENSACIP00000018637 | ENSACIP00000001652 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. | 0.677 |
| ADSSL1 | ENSACIP00000006564 | ENSACIP00000018637 | ENSACIP00000006564 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.771 |
| ADSSL1 | ENSACIP00000011053 | ENSACIP00000018637 | ENSACIP00000011053 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.865 |
| ADSSL1 | ENSACIP00000018916 | ENSACIP00000018637 | ENSACIP00000018916 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.865 |
| ADSSL1 | ENSACIP00000022766 | ENSACIP00000018637 | ENSACIP00000022766 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Argininosuccinate lyase. | 0.777 |
| ADSSL1 | ENSACIP00000028189 | ENSACIP00000018637 | ENSACIP00000028189 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Carbamoyl-phosphate synthase 1, mitochondrial. | 0.900 |
| ADSSL1 | ENSACIP00000029871 | ENSACIP00000018637 | ENSACIP00000029871 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.890 |
| ASS1 | ADSSL1 | ENSACIP00000025357 | ENSACIP00000018637 | Argininosuccinate synthase 1. | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.937 |
| ASS1 | ENSACIP00000001356 | ENSACIP00000025357 | ENSACIP00000001356 | Argininosuccinate synthase 1. | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | 0.986 |
| ASS1 | ENSACIP00000011053 | ENSACIP00000025357 | ENSACIP00000011053 | Argininosuccinate synthase 1. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.937 |
| ASS1 | ENSACIP00000018916 | ENSACIP00000025357 | ENSACIP00000018916 | Argininosuccinate synthase 1. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.937 |
| ASS1 | ENSACIP00000022766 | ENSACIP00000025357 | ENSACIP00000022766 | Argininosuccinate synthase 1. | Argininosuccinate lyase. | 0.998 |
| ASS1 | ENSACIP00000028189 | ENSACIP00000025357 | ENSACIP00000028189 | Argininosuccinate synthase 1. | Carbamoyl-phosphate synthase 1, mitochondrial. | 0.994 |
| ASS1 | ENSACIP00000028847 | ENSACIP00000025357 | ENSACIP00000028847 | Argininosuccinate synthase 1. | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. | 0.997 |
| ASS1 | ENSACIP00000029871 | ENSACIP00000025357 | ENSACIP00000029871 | Argininosuccinate synthase 1. | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.880 |
| ENSACIP00000001356 | ADSSL1 | ENSACIP00000001356 | ENSACIP00000018637 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.929 |
| ENSACIP00000001356 | ASS1 | ENSACIP00000001356 | ENSACIP00000025357 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Argininosuccinate synthase 1. | 0.986 |
| ENSACIP00000001356 | ENSACIP00000001652 | ENSACIP00000001356 | ENSACIP00000001652 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. | 0.922 |