Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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Score
ENSACIP00000001456S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (362 aa)    
Predicted Functional Partners:
ENSACIP00000028728
Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.
  
 0.986
ENSACIP00000003211
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.917
ENSACIP00000008560
S-adenosylmethionine decarboxylase proenzyme.
   
 
 0.913
ENSACIP00000004348
Glycine N-methyltransferase.
   
 
 0.912
ENSACIP00000010399
Zgc:172121; Involved in the regulation of homocysteine metabolism.
  
 
 0.912
ENSACIP00000008269
Amine oxidase.
   
 0.908
ENSACIP00000019200
Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.
  
 0.905
ENSACIP00000010930
Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.901
ENSACIP00000006977
Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism.
  
 
 0.900
ENSACIP00000021144
Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism.
  
 
 0.900
Your Current Organism:
Amphilophus citrinellus
NCBI taxonomy Id: 61819
Other names: A. citrinellus, Archocentrus citrinellum, Cichlasoma citrinellum, Herichthys citrinellus, Heros citrinellus, Midas cichlid, red devil, red devil cichlid
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