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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSACIP00000001876Si:ch211-253p14.2. (425 aa)    
Predicted Functional Partners:
ENSACIP00000006062
CULLIN_2 domain-containing protein; Belongs to the cullin family.
    
 0.701
CUL3
Cullin 3; Belongs to the cullin family.
    
 0.701
ENSACIP00000008151
COMM domain containing 5.
  
  
  0.699
ENSACIP00000027906
NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
     
 0.697
ENSACIP00000012470
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.643
ENSACIP00000003567
COMM domain containing 4.
     
 0.633
ENSACIP00000019804
Ubiquitin-conjugating enzyme E2F (putative); Belongs to the ubiquitin-conjugating enzyme family.
    
  0.621
ENSACIP00000029975
Uncharacterized protein.
    
  0.621
ENSACIP00000003379
Cullin 1b; Belongs to the cullin family.
    
 0.611
NEDD8
NEDD8 ubiquitin like modifier.
     
 0.601
Your Current Organism:
Amphilophus citrinellus
NCBI taxonomy Id: 61819
Other names: A. citrinellus, Archocentrus citrinellum, Cichlasoma citrinellum, Herichthys citrinellus, Heros citrinellus, Midas cichlid, red devil, red devil cichlid
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.