Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ENSACIP00000002103E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1808 aa)    
Predicted Functional Partners:
ENSACIP00000015409
HECT domain-containing protein.
   
  
 0.776
ENSACIP00000015430
Uncharacterized protein.
   
  
 0.776
CUL5
Cullin 5; Belongs to the cullin family.
   
    0.737
ENSACIP00000022008
CULLIN_2 domain-containing protein; Belongs to the cullin family.
   
    0.737
ENSACIP00000015436
Thyroid hormone receptor interactor 12.
   
 
 0.714
ENSACIP00000005813
Cadherin-related 23.
    
 
 0.703
ENSACIP00000015443
Mitochondrial intermediate peptidase.
      
 0.700
ENSACIP00000017566
Ubiquitin-conjugating enzyme E2B (RAD6 homolog); Belongs to the ubiquitin-conjugating enzyme family.
    
 
 0.649
ENSACIP00000017590
Ubiquitin-conjugating enzyme E2A (RAD6 homolog); Belongs to the ubiquitin-conjugating enzyme family.
    
 
 0.649
ENSACIP00000029598
Ubiquitin conjugating enzyme E2 A, like.
    
 
 0.649
Your Current Organism:
Amphilophus citrinellus
NCBI taxonomy Id: 61819
Other names: A. citrinellus, Archocentrus citrinellum, Cichlasoma citrinellum, Herichthys citrinellus, Heros citrinellus, Midas cichlid, red devil, red devil cichlid
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