| node1 | node2 | node1 annotation | node2 annotation | score |
| ENSACIP00000002123 | ENSACIP00000003745 | Sulfotransferase; Belongs to the sulfotransferase 1 family. | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 0.797 |
| ENSACIP00000002123 | ENSACIP00000007415 | Sulfotransferase; Belongs to the sulfotransferase 1 family. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.787 |
| ENSACIP00000002123 | ENSACIP00000008322 | Sulfotransferase; Belongs to the sulfotransferase 1 family. | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | 0.747 |
| ENSACIP00000002123 | ENSACIP00000008746 | Sulfotransferase; Belongs to the sulfotransferase 1 family. | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. | 0.852 |
| ENSACIP00000002123 | ENSACIP00000009031 | Sulfotransferase; Belongs to the sulfotransferase 1 family. | Cytochrome P450, family 7, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | 0.825 |
| ENSACIP00000002123 | ENSACIP00000009091 | Sulfotransferase; Belongs to the sulfotransferase 1 family. | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; Belongs to the 3-beta-HSD family. | 0.787 |
| ENSACIP00000002123 | ENSACIP00000017247 | Sulfotransferase; Belongs to the sulfotransferase 1 family. | 24-dehydrocholesterol reductase. | 0.787 |
| ENSACIP00000002123 | ENSACIP00000018357 | Sulfotransferase; Belongs to the sulfotransferase 1 family. | 7-dehydrocholesterol reductase. | 0.810 |
| ENSACIP00000002123 | ENSACIP00000021476 | Sulfotransferase; Belongs to the sulfotransferase 1 family. | Sterol O-acyltransferase 2; Belongs to the membrane-bound acyltransferase family. | 0.787 |
| ENSACIP00000002123 | ENSACIP00000022734 | Sulfotransferase; Belongs to the sulfotransferase 1 family. | Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | 0.799 |
| ENSACIP00000003745 | ENSACIP00000002123 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Sulfotransferase; Belongs to the sulfotransferase 1 family. | 0.797 |
| ENSACIP00000003745 | ENSACIP00000007415 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.873 |
| ENSACIP00000003745 | ENSACIP00000008322 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | 0.674 |
| ENSACIP00000003745 | ENSACIP00000008746 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. | 0.956 |
| ENSACIP00000003745 | ENSACIP00000009031 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Cytochrome P450, family 7, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | 0.815 |
| ENSACIP00000003745 | ENSACIP00000009091 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; Belongs to the 3-beta-HSD family. | 0.943 |
| ENSACIP00000003745 | ENSACIP00000017247 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 24-dehydrocholesterol reductase. | 0.888 |
| ENSACIP00000003745 | ENSACIP00000018357 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 7-dehydrocholesterol reductase. | 0.909 |
| ENSACIP00000003745 | ENSACIP00000021476 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Sterol O-acyltransferase 2; Belongs to the membrane-bound acyltransferase family. | 0.871 |
| ENSACIP00000003745 | ENSACIP00000022734 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | 0.940 |
