Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ENSACIP00000002134Pleckstrin homology domain containing, family O member 1a. (554 aa)    
Predicted Functional Partners:
SMURF2
E3 ubiquitin-protein ligase.
    
 
 0.724
SMURF1
SMAD specific E3 ubiquitin protein ligase 1.
    
 
 0.724
ENSACIP00000028907
C2 domain-containing protein.
    
 
 0.724
ENSACIP00000028932
SMAD specific E3 ubiquitin protein ligase 2.
    
 
 0.724
ENSACIP00000003458
Cyclin B2; Belongs to the cyclin family.
    
   0.710
ENSACIP00000026029
Cyclin N-terminal domain containing 2; Belongs to the cyclin family.
    
   0.710
ENSACIP00000026160
Cyclin B1; Belongs to the cyclin family.
    
   0.710
ENSACIP00000025055
F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
    
   0.704
ENSACIP00000006083
Cyclin B3; Belongs to the cyclin family.
    
   0.508
ENSACIP00000021484
WD repeat domain 41.
    
   0.508
Your Current Organism:
Amphilophus citrinellus
NCBI taxonomy Id: 61819
Other names: A. citrinellus, Archocentrus citrinellum, Cichlasoma citrinellum, Herichthys citrinellus, Heros citrinellus, Midas cichlid, red devil, red devil cichlid
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