Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Experiments
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[Homology]
Score
ENSACIP00000002841Timeless circadian clock. (1169 aa)    
Predicted Functional Partners:
ENSACIP00000004066
TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.
   
 0.999
MCM7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
   
 
 0.993
ENSACIP00000027828
WD repeat and HMG-box DNA binding protein 1.
   
 
 0.989
ENSACIP00000010300
GINS complex subunit 3.
   
 
 0.987
CLSPN
Claspin.
   
 0.987
ENSACIP00000026928
Primase and polymerase (DNA-directed).
    
 
 0.986
ENSACIP00000028611
DNA helicase; Belongs to the MCM family.
   
 
 0.984
ENSACIP00000004243
Checkpoint kinase 1; Belongs to the protein kinase superfamily.
   
 0.983
ENSACIP00000002494
DNA polymerase.
   
 
 0.982
ENSACIP00000012457
DNA helicase; Belongs to the MCM family.
   
 
 0.982
Your Current Organism:
Amphilophus citrinellus
NCBI taxonomy Id: 61819
Other names: A. citrinellus, Archocentrus citrinellum, Cichlasoma citrinellum, Herichthys citrinellus, Heros citrinellus, Midas cichlid, red devil, red devil cichlid
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