Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ENSACIP00000004093Uncharacterized protein. (842 aa)    
Predicted Functional Partners:
ENSACIP00000003379
Cullin 1b; Belongs to the cullin family.
   
 0.976
ENSACIP00000017602
S-phase kinase-associated protein 1; Belongs to the SKP1 family.
    
 0.963
ENSACIP00000012470
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.950
ENSACIP00000006062
CULLIN_2 domain-containing protein; Belongs to the cullin family.
   
 0.809
CUL3
Cullin 3; Belongs to the cullin family.
   
 0.809
ENSACIP00000020373
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.782
ENSACIP00000017528
Denticleless E3 ubiquitin protein ligase homolog (Drosophila).
    
 
 0.774
ENSACIP00000026041
F-box and leucine-rich repeat protein 2.
   
 
 0.770
ENSACIP00000008151
COMM domain containing 5.
     
 0.747
PAFAH1B1-2
Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family.
   
 
 0.715
Your Current Organism:
Amphilophus citrinellus
NCBI taxonomy Id: 61819
Other names: A. citrinellus, Archocentrus citrinellum, Cichlasoma citrinellum, Herichthys citrinellus, Heros citrinellus, Midas cichlid, red devil, red devil cichlid
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