Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ENSACIP00000004231Apoptosis inducing factor mitochondria associated 2. (371 aa)    
Predicted Functional Partners:
ENSACIP00000002689
Sulfite oxidase.
   
 0.914
ENSACIP00000018440
Trimethyllysine hydroxylase, epsilon.
      
 0.887
CDKAL1
CDK5 regulatory subunit associated protein 1 like 1.
     
 0.868
ENSACIP00000006087
Cytochrome b5 reductase 4.
    
 0.840
ENSACIP00000020373
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.805
ENSACIP00000025644
Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
  
 0.771
ENSACIP00000008887
Immunoresponsive gene 1, like.
   
 0.735
ENSACIP00000011242
Zgc:172341.
   
 0.735
ENSACIP00000014936
Pipecolic acid oxidase.
   
 0.735
ENSACIP00000021381
D-amino-acid oxidase, tandem duplicate 2.
   
 0.735
Your Current Organism:
Amphilophus citrinellus
NCBI taxonomy Id: 61819
Other names: A. citrinellus, Archocentrus citrinellum, Cichlasoma citrinellum, Herichthys citrinellus, Heros citrinellus, Midas cichlid, red devil, red devil cichlid
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