Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ENSACIP00000004575Ankyrin repeat, family A (RFXANK-like), 2. (317 aa)    
Predicted Functional Partners:
ENSACIP00000030392
Regulatory factor X-associated protein.
    
 0.983
ENSACIP00000001531
Regulatory factor X, 5.
    
 0.917
HDAC3
Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
   
 0.796
ENSACIP00000018064
Transmembrane protein 59-like.
   
 0.712
ENSACIP00000019378
Regulatory factor X7b.
   
 0.693
RFX7
Regulatory factor X7.
   
 0.689
ENSACIP00000003007
Regulatory factor X, 6.
    
 0.676
ENSACIP00000007500
Regulatory factor X, 4.
    
 0.676
ENSACIP00000009725
Regulatory factor X, 1a (influences HLA class II expression).
    
 0.676
ENSACIP00000012179
Regulatory factor X, 1b (influences HLA class II expression).
    
 0.676
Your Current Organism:
Amphilophus citrinellus
NCBI taxonomy Id: 61819
Other names: A. citrinellus, Archocentrus citrinellum, Cichlasoma citrinellum, Herichthys citrinellus, Heros citrinellus, Midas cichlid, red devil, red devil cichlid
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