Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (723 aa)    
Predicted Functional Partners:
ENSACIP00000007409
Minichromosome maintenance 10 replication initiation factor.
   
 0.999
ENSACIP00000008271
CDC45 cell division cycle 45 homolog (S. cerevisiae).
   
 0.999
ENSACIP00000010745
DNA helicase; Belongs to the MCM family.
   
0.999
ENSACIP00000012457
DNA helicase; Belongs to the MCM family.
   
0.999
ENSACIP00000015692
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
   
 0.999
ENSACIP00000020764
Chromatin licensing and DNA replication factor 1.
   
 0.999
ENSACIP00000023747
DNA helicase; Belongs to the MCM family.
  
0.999
ENSACIP00000028611
DNA helicase; Belongs to the MCM family.
   
0.999
ENSACIP00000028668
DNA helicase; Belongs to the MCM family.
   
0.999
ENSACIP00000002363
Origin recognition complex, subunit 1.
   
 0.998
Your Current Organism:
Amphilophus citrinellus
NCBI taxonomy Id: 61819
Other names: A. citrinellus, Archocentrus citrinellum, Cichlasoma citrinellum, Herichthys citrinellus, Heros citrinellus, Midas cichlid, red devil, red devil cichlid
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