Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
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[Homology]
Score
SMAD6Mothers against decapentaplegic homolog. (335 aa)    
Predicted Functional Partners:
SMURF2
E3 ubiquitin-protein ligase.
    
 0.973
SMURF1
SMAD specific E3 ubiquitin protein ligase 1.
    
 0.973
ENSACIP00000028907
C2 domain-containing protein.
    
 0.973
ENSACIP00000028932
SMAD specific E3 ubiquitin protein ligase 2.
    
 0.973
ENSACIP00000005135
Mothers against decapentaplegic homolog.
    
0.972
ENSACIP00000007979
Mothers against decapentaplegic homolog.
    
0.972
ENSACIP00000018335
Mothers against decapentaplegic homolog.
    
0.972
SMAD3
Mothers against decapentaplegic homolog.
    
0.972
ENSACIP00000021648
Mothers against decapentaplegic homolog.
    
0.972
ENSACIP00000030390
Mothers against decapentaplegic homolog.
    
0.972
Your Current Organism:
Amphilophus citrinellus
NCBI taxonomy Id: 61819
Other names: A. citrinellus, Archocentrus citrinellum, Cichlasoma citrinellum, Herichthys citrinellus, Heros citrinellus, Midas cichlid, red devil, red devil cichlid
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