Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ENSACIP00000005311Alpha and gamma adaptin binding protein. (321 aa)    
Predicted Functional Partners:
ENSACIP00000025451
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
    
 
 0.990
ENSACIP00000031073
Coiled-coil domain containing 32.
    
   0.959
ENSACIP00000011286
AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]
    
 
 0.956
ENSACIP00000022937
AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]
    
 
 0.931
ENSACIP00000001911
AP-1 complex subunit gamma.
    
 
 0.926
ENSACIP00000029508
ADP-ribosylation factor GTPase activating protein 1.
    
   0.890
ENSACIP00000007609
AP-1 complex subunit gamma.
    
 
 0.852
ENSACIP00000029501
Major facilitator superfamily domain containing 9.
      
 0.794
ENSACIP00000029668
Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family.
    
   0.739
ENSACIP00000008727
Exocyst complex component 5.
      
 0.698
Your Current Organism:
Amphilophus citrinellus
NCBI taxonomy Id: 61819
Other names: A. citrinellus, Archocentrus citrinellum, Cichlasoma citrinellum, Herichthys citrinellus, Heros citrinellus, Midas cichlid, red devil, red devil cichlid
Server load: low (32%) [HD]