Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ENSACIP00000005328HECT and RLD domain containing E3 ubiquitin protein ligase 4. (1045 aa)    
Predicted Functional Partners:
ENSACIP00000020373
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.883
ENSACIP00000012575
TSC complex subunit 2.
    
 0.822
ENSACIP00000023514
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.816
ENSACIP00000025985
Catenin (cadherin-associated protein), beta 1.
    
 0.803
ENSACIP00000007164
Nuclear transcription factor, X-box binding-like 1.
    
 0.738
NFX1
Nuclear transcription factor, X-box binding 1.
    
 0.738
UBE2L3
Ubiquitin-conjugating enzyme E2L 3b; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.725
ENSACIP00000002663
TSC complex subunit 1b.
    
 0.711
ENSACIP00000007517
Uncharacterized protein.
    
 0.711
ENSACIP00000004126
Ribosomal protein S27a.
    
 0.705
Your Current Organism:
Amphilophus citrinellus
NCBI taxonomy Id: 61819
Other names: A. citrinellus, Archocentrus citrinellum, Cichlasoma citrinellum, Herichthys citrinellus, Heros citrinellus, Midas cichlid, red devil, red devil cichlid
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