ENSACIP00000005752 protein (Amphilophus citrinellus)

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ENSACIP00000005752

DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (561 aa)

Predicted Functional Partners:

ENSACIP00000010043

0.923

ENSACIP00000007255

0.915

ENSACIP00000003342

0.884

ENSACIP00000030785

0.881

ENSACIP00000012372

0.874

ENSACIP00000000966

0.873

ENSACIP00000002259

0.864

ENSACIP00000002841

0.863

ENSACIP00000005836

0.855

ENSACIP00000003287

0.854

Your Current Organism:

Amphilophus citrinellus

NCBI taxonomy Id: 61819
Other names: A. citrinellus, Archocentrus citrinellum, Cichlasoma citrinellum, Herichthys citrinellus, Heros citrinellus, Midas cichlid, red devil, red devil cichlid

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSACIP00000000966	ENSACIP00000002259	MUS81 structure-specific endonuclease subunit.	X-ray repair complementing defective repair in Chinese hamster cells 5.	0.705
ENSACIP00000000966	ENSACIP00000002841	MUS81 structure-specific endonuclease subunit.	Timeless circadian clock.	0.907
ENSACIP00000000966	ENSACIP00000003342	MUS81 structure-specific endonuclease subunit.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.636
ENSACIP00000000966	ENSACIP00000005752	MUS81 structure-specific endonuclease subunit.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.873
ENSACIP00000000966	ENSACIP00000005836	MUS81 structure-specific endonuclease subunit.	RAD52 homolog, DNA repair protein.	0.977
ENSACIP00000000966	ENSACIP00000007255	MUS81 structure-specific endonuclease subunit.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.423
ENSACIP00000000966	ENSACIP00000010043	MUS81 structure-specific endonuclease subunit.	Tyrosyl-DNA phosphodiesterase 1.	0.931
ENSACIP00000000966	ENSACIP00000030785	MUS81 structure-specific endonuclease subunit.	BLM RecQ like helicase.	0.987
ENSACIP00000002259	ENSACIP00000000966	X-ray repair complementing defective repair in Chinese hamster cells 5.	MUS81 structure-specific endonuclease subunit.	0.705
ENSACIP00000002259	ENSACIP00000005752	X-ray repair complementing defective repair in Chinese hamster cells 5.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.864
ENSACIP00000002259	ENSACIP00000005836	X-ray repair complementing defective repair in Chinese hamster cells 5.	RAD52 homolog, DNA repair protein.	0.958
ENSACIP00000002259	ENSACIP00000007255	X-ray repair complementing defective repair in Chinese hamster cells 5.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.988
ENSACIP00000002259	ENSACIP00000010043	X-ray repair complementing defective repair in Chinese hamster cells 5.	Tyrosyl-DNA phosphodiesterase 1.	0.899
ENSACIP00000002259	ENSACIP00000012372	X-ray repair complementing defective repair in Chinese hamster cells 5.	SPT16 homolog, facilitates chromatin remodeling subunit.	0.678
ENSACIP00000002259	ENSACIP00000030785	X-ray repair complementing defective repair in Chinese hamster cells 5.	BLM RecQ like helicase.	0.951
ENSACIP00000002841	ENSACIP00000000966	Timeless circadian clock.	MUS81 structure-specific endonuclease subunit.	0.907
ENSACIP00000002841	ENSACIP00000003342	Timeless circadian clock.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.683
ENSACIP00000002841	ENSACIP00000005752	Timeless circadian clock.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.863
ENSACIP00000002841	ENSACIP00000005836	Timeless circadian clock.	RAD52 homolog, DNA repair protein.	0.727
ENSACIP00000002841	ENSACIP00000007255	Timeless circadian clock.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.905

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