| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AFMID | ENSACIP00000006296 | ENSACIP00000010590 | ENSACIP00000006296 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Indoleamine 2,3-dioxygenase 1. | 0.941 |
| AFMID | KYNU | ENSACIP00000010590 | ENSACIP00000031605 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. | 0.969 |
| AFMID | TDO2 | ENSACIP00000010590 | ENSACIP00000003031 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.968 |
| ENSACIP00000002073 | ENSACIP00000002778 | ENSACIP00000002073 | ENSACIP00000002778 | Amine oxidase. | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.491 |
| ENSACIP00000002073 | ENSACIP00000006296 | ENSACIP00000002073 | ENSACIP00000006296 | Amine oxidase. | Indoleamine 2,3-dioxygenase 1. | 0.899 |
| ENSACIP00000002073 | ENSACIP00000011166 | ENSACIP00000002073 | ENSACIP00000011166 | Amine oxidase. | Uncharacterized protein. | 0.565 |
| ENSACIP00000002073 | ENSACIP00000018103 | ENSACIP00000002073 | ENSACIP00000018103 | Amine oxidase. | Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. | 0.491 |
| ENSACIP00000002073 | ENSACIP00000020341 | ENSACIP00000002073 | ENSACIP00000020341 | Amine oxidase. | Tryptophan hydroxylase 2 (tryptophan 5-monooxygenase). | 0.565 |
| ENSACIP00000002073 | ENSACIP00000031049 | ENSACIP00000002073 | ENSACIP00000031049 | Amine oxidase. | Amine oxidase. | 0.865 |
| ENSACIP00000002073 | KYNU | ENSACIP00000002073 | ENSACIP00000031605 | Amine oxidase. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. | 0.408 |
| ENSACIP00000002073 | TDO2 | ENSACIP00000002073 | ENSACIP00000003031 | Amine oxidase. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.703 |
| ENSACIP00000002073 | TPH1 | ENSACIP00000002073 | ENSACIP00000014666 | Amine oxidase. | Tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a. | 0.565 |
| ENSACIP00000002778 | ENSACIP00000002073 | ENSACIP00000002778 | ENSACIP00000002073 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Amine oxidase. | 0.491 |
| ENSACIP00000002778 | ENSACIP00000006296 | ENSACIP00000002778 | ENSACIP00000006296 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Indoleamine 2,3-dioxygenase 1. | 0.919 |
| ENSACIP00000002778 | ENSACIP00000031049 | ENSACIP00000002778 | ENSACIP00000031049 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Amine oxidase. | 0.491 |
| ENSACIP00000002778 | TDO2 | ENSACIP00000002778 | ENSACIP00000003031 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.424 |
| ENSACIP00000006296 | AFMID | ENSACIP00000006296 | ENSACIP00000010590 | Indoleamine 2,3-dioxygenase 1. | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | 0.941 |
| ENSACIP00000006296 | ENSACIP00000002073 | ENSACIP00000006296 | ENSACIP00000002073 | Indoleamine 2,3-dioxygenase 1. | Amine oxidase. | 0.899 |
| ENSACIP00000006296 | ENSACIP00000002778 | ENSACIP00000006296 | ENSACIP00000002778 | Indoleamine 2,3-dioxygenase 1. | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.919 |
| ENSACIP00000006296 | ENSACIP00000011166 | ENSACIP00000006296 | ENSACIP00000011166 | Indoleamine 2,3-dioxygenase 1. | Uncharacterized protein. | 0.891 |