Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ENSACIP00000006877Hepatocyte nuclear factor 4, alpha. (438 aa)    
Predicted Functional Partners:
ENSACIP00000025985
Catenin (cadherin-associated protein), beta 1.
    
 
 0.918
ENSACIP00000013570
Nuclear receptor subfamily 0, group B, member 2a.
   
 0.905
ENSACIP00000012507
Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.
    
 
 0.902
ENSACIP00000031671
Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 0.823
ENSACIP00000020373
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.816
ENSACIP00000023552
HNF1 homeobox a.
   
 0.814
ENSACIP00000020437
CREB binding protein b.
    
 
 0.809
ENSACIP00000020520
CREB binding protein a.
    
 
 0.809
ENSACIP00000021715
Sp1 transcription factor.
    
 
 0.788
ENSACIP00000010491
HNF1 homeobox Ba.
   
 0.761
Your Current Organism:
Amphilophus citrinellus
NCBI taxonomy Id: 61819
Other names: A. citrinellus, Archocentrus citrinellum, Cichlasoma citrinellum, Herichthys citrinellus, Heros citrinellus, Midas cichlid, red devil, red devil cichlid
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