node1 | node2 | node1 annotation | node2 annotation | score |
ENSACIP00000000966 | ENSACIP00000001067 | MUS81 structure-specific endonuclease subunit. | X-ray repair complementing defective repair in Chinese hamster cells 1. | 0.461 |
ENSACIP00000000966 | ENSACIP00000002259 | MUS81 structure-specific endonuclease subunit. | X-ray repair complementing defective repair in Chinese hamster cells 5. | 0.661 |
ENSACIP00000000966 | ENSACIP00000005752 | MUS81 structure-specific endonuclease subunit. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.723 |
ENSACIP00000000966 | ENSACIP00000008246 | MUS81 structure-specific endonuclease subunit. | Excision repair cross-complementation group 4. | 0.978 |
ENSACIP00000000966 | ENSACIP00000010043 | MUS81 structure-specific endonuclease subunit. | Tyrosyl-DNA phosphodiesterase 1. | 0.832 |
ENSACIP00000000966 | ENSACIP00000012294 | MUS81 structure-specific endonuclease subunit. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.723 |
ENSACIP00000000966 | ENSACIP00000014476 | MUS81 structure-specific endonuclease subunit. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.723 |
ENSACIP00000000966 | ENSACIP00000027468 | MUS81 structure-specific endonuclease subunit. | X-ray repair complementing defective repair in Chinese hamster cells 6. | 0.677 |
ENSACIP00000001067 | ENSACIP00000000966 | X-ray repair complementing defective repair in Chinese hamster cells 1. | MUS81 structure-specific endonuclease subunit. | 0.461 |
ENSACIP00000001067 | ENSACIP00000002259 | X-ray repair complementing defective repair in Chinese hamster cells 1. | X-ray repair complementing defective repair in Chinese hamster cells 5. | 0.582 |
ENSACIP00000001067 | ENSACIP00000005752 | X-ray repair complementing defective repair in Chinese hamster cells 1. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.416 |
ENSACIP00000001067 | ENSACIP00000008246 | X-ray repair complementing defective repair in Chinese hamster cells 1. | Excision repair cross-complementation group 4. | 0.404 |
ENSACIP00000001067 | ENSACIP00000010043 | X-ray repair complementing defective repair in Chinese hamster cells 1. | Tyrosyl-DNA phosphodiesterase 1. | 0.840 |
ENSACIP00000001067 | ENSACIP00000012294 | X-ray repair complementing defective repair in Chinese hamster cells 1. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.416 |
ENSACIP00000001067 | ENSACIP00000014476 | X-ray repair complementing defective repair in Chinese hamster cells 1. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.416 |
ENSACIP00000001067 | ENSACIP00000017671 | X-ray repair complementing defective repair in Chinese hamster cells 1. | DNA ligase. | 0.999 |
ENSACIP00000001067 | ENSACIP00000023702 | X-ray repair complementing defective repair in Chinese hamster cells 1. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.982 |
ENSACIP00000001067 | ENSACIP00000027468 | X-ray repair complementing defective repair in Chinese hamster cells 1. | X-ray repair complementing defective repair in Chinese hamster cells 6. | 0.849 |
ENSACIP00000002259 | ENSACIP00000000966 | X-ray repair complementing defective repair in Chinese hamster cells 5. | MUS81 structure-specific endonuclease subunit. | 0.661 |
ENSACIP00000002259 | ENSACIP00000001067 | X-ray repair complementing defective repair in Chinese hamster cells 5. | X-ray repair complementing defective repair in Chinese hamster cells 1. | 0.582 |