node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCAF7 | ENSACIP00000019274 | ENSACIP00000009254 | ENSACIP00000019274 | DDB1 and CUL4 associated factor 7. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.664 |
ENSACIP00000005753 | ENSACIP00000019274 | ENSACIP00000005753 | ENSACIP00000019274 | MBD domain-containing protein. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.600 |
ENSACIP00000005753 | ENSACIP00000020373 | ENSACIP00000005753 | ENSACIP00000020373 | MBD domain-containing protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.483 |
ENSACIP00000010178 | ENSACIP00000019274 | ENSACIP00000010178 | ENSACIP00000019274 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.613 |
ENSACIP00000010178 | ENSACIP00000020373 | ENSACIP00000010178 | ENSACIP00000020373 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.945 |
ENSACIP00000010178 | ENSACIP00000020907 | ENSACIP00000010178 | ENSACIP00000020907 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | Small ubiquitin-related modifier. | 0.679 |
ENSACIP00000010178 | ENSACIP00000030495 | ENSACIP00000010178 | ENSACIP00000030495 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | Peptidyl-prolyl cis-trans isomerase. | 0.767 |
ENSACIP00000018075 | ENSACIP00000019274 | ENSACIP00000018075 | ENSACIP00000019274 | WD_REPEATS_REGION domain-containing protein. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.664 |
ENSACIP00000019274 | DCAF7 | ENSACIP00000019274 | ENSACIP00000009254 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | DDB1 and CUL4 associated factor 7. | 0.664 |
ENSACIP00000019274 | ENSACIP00000005753 | ENSACIP00000019274 | ENSACIP00000005753 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | MBD domain-containing protein. | 0.600 |
ENSACIP00000019274 | ENSACIP00000010178 | ENSACIP00000019274 | ENSACIP00000010178 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | 0.613 |
ENSACIP00000019274 | ENSACIP00000018075 | ENSACIP00000019274 | ENSACIP00000018075 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | WD_REPEATS_REGION domain-containing protein. | 0.664 |
ENSACIP00000019274 | ENSACIP00000020353 | ENSACIP00000019274 | ENSACIP00000020353 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Core-binding factor subunit beta. | 0.563 |
ENSACIP00000019274 | ENSACIP00000020373 | ENSACIP00000019274 | ENSACIP00000020373 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.713 |
ENSACIP00000019274 | ENSACIP00000020907 | ENSACIP00000019274 | ENSACIP00000020907 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Small ubiquitin-related modifier. | 0.594 |
ENSACIP00000019274 | ENSACIP00000028551 | ENSACIP00000019274 | ENSACIP00000028551 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | 0.613 |
ENSACIP00000019274 | ENSACIP00000030495 | ENSACIP00000019274 | ENSACIP00000030495 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Peptidyl-prolyl cis-trans isomerase. | 0.652 |
ENSACIP00000019274 | RASSF5 | ENSACIP00000019274 | ENSACIP00000029802 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Ras association domain family member 5. | 0.574 |
ENSACIP00000020353 | ENSACIP00000019274 | ENSACIP00000020353 | ENSACIP00000019274 | Core-binding factor subunit beta. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.563 |
ENSACIP00000020373 | ENSACIP00000005753 | ENSACIP00000020373 | ENSACIP00000005753 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | MBD domain-containing protein. | 0.483 |