close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EWB00_002780Uracil-DNA glycosylase. (714 aa)    
Predicted Functional Partners:
EWB00_006793
DDB1-and CUL4-associated factor 1.
    
 
 0.922
NTH1
Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.
   
 0.897
EWB00_002651
DNA damage-binding protein isoform 2.
    
 
 0.863
EWB00_006433
DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.
  
 0.856
EWB00_000510
DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.
  
 0.822
EWB00_004659
Mitochondrial coenzyme A transporter SLC25A42; Belongs to the mitochondrial carrier (TC 2.A.29) family.
  
 
 0.807
EWB00_008705
Replication protein A 32 kDa subunit isoform 3.
   
 
 0.800
EWB00_007607
Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM.
  
 0.793
EWB00_006005
Thymidylate synthase isoform 3.
  
 
 0.721
EWB00_010065
Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.
     
 0.714
Your Current Organism:
Schistosoma japonicum
NCBI taxonomy Id: 6182
Other names: S. japonicum
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.