EWB00_000295 protein (Schistosoma japonicum)

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EWB00_000295

RecQ-mediated genome instability protein. (883 aa)

Predicted Functional Partners:

EWB00_001304

0.999

EWB00_003961

0.995

EWB00_003874

0.989

EWB00_008705

0.981

EWB00_009894

0.974

EWB00_000311

0.974

EWB00_010425

0.969

EWB00_005561

0.939

EWB00_005242

0.911

EWB00_001249

0.911

Your Current Organism:

Schistosoma japonicum

NCBI taxonomy Id: 6182
Other names: S. japonicum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EWB00_000295	EWB00_000311	A0A4Z2DJI4	A0A4Z2DX57	RecQ-mediated genome instability protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.974
EWB00_000295	EWB00_001249	A0A4Z2DJI4	A0A4Z2DH68	RecQ-mediated genome instability protein.	Crossover junction endonuclease MUS81.	0.911
EWB00_000295	EWB00_001304	A0A4Z2DJI4	A0A4Z2DG70	RecQ-mediated genome instability protein.	Fanconi anemia group M protein isoform 1.	0.999
EWB00_000295	EWB00_003874	A0A4Z2DJI4	A0A4Z2D776	RecQ-mediated genome instability protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.989
EWB00_000295	EWB00_003961	A0A4Z2DJI4	A0A4Z2D6W0	RecQ-mediated genome instability protein.	Bloom syndrome protein.	0.995
EWB00_000295	EWB00_005242	A0A4Z2DJI4	A0A4Z2D267	RecQ-mediated genome instability protein.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.	0.911
EWB00_000295	EWB00_005561	A0A4Z2DJI4	A0A4Z2D179	RecQ-mediated genome instability protein.	ATP-dependent DNA helicase Q4 isoform 2.	0.939
EWB00_000295	EWB00_008705	A0A4Z2DJI4	A0A4Z2CPG0	RecQ-mediated genome instability protein.	Replication protein A 32 kDa subunit isoform 3.	0.981
EWB00_000295	EWB00_009894	A0A4Z2DJI4	A0A4Z2CLA8	RecQ-mediated genome instability protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.974
EWB00_000295	EWB00_010425	A0A4Z2DJI4	A0A4Z2DXM1	RecQ-mediated genome instability protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.969
EWB00_000311	EWB00_000295	A0A4Z2DX57	A0A4Z2DJI4	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	RecQ-mediated genome instability protein.	0.974
EWB00_000311	EWB00_001249	A0A4Z2DX57	A0A4Z2DH68	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Crossover junction endonuclease MUS81.	0.890
EWB00_000311	EWB00_001304	A0A4Z2DX57	A0A4Z2DG70	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Fanconi anemia group M protein isoform 1.	0.999
EWB00_000311	EWB00_003874	A0A4Z2DX57	A0A4Z2D776	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.963
EWB00_000311	EWB00_003961	A0A4Z2DX57	A0A4Z2D6W0	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Bloom syndrome protein.	0.975
EWB00_000311	EWB00_005242	A0A4Z2DX57	A0A4Z2D267	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.	0.891
EWB00_000311	EWB00_005561	A0A4Z2DX57	A0A4Z2D179	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	ATP-dependent DNA helicase Q4 isoform 2.	0.927
EWB00_000311	EWB00_008705	A0A4Z2DX57	A0A4Z2CPG0	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Replication protein A 32 kDa subunit isoform 3.	0.972
EWB00_000311	EWB00_010425	A0A4Z2DX57	A0A4Z2DXM1	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.917
EWB00_001249	EWB00_000295	A0A4Z2DH68	A0A4Z2DJI4	Crossover junction endonuclease MUS81.	RecQ-mediated genome instability protein.	0.911