c5016_g1_i1 protein (Schistosoma mansoni) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

c5016_g1_i1

Uncharacterized protein. (68 aa)

Predicted Functional Partners:

A0A3Q0KFH7

0.999

A0A3Q0KTS6

0.999

A0A3Q0KV34

0.999

A0A3Q0KVH7

0.999

A0A5K4F5A7

0.999

A0A5K4F6K1

0.999

A0A5K4F7C5

0.999

A0A5K4FBY9

0.999

A0A5K4FC15

0.999

A0A5K4FC25

0.999

Your Current Organism:

Schistosoma mansoni

NCBI taxonomy Id: 6183
Other names: S. mansoni

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A3Q0KFH7	A0A3Q0KTS6	A0A3Q0KFH7	A0A3Q0KTS6	Putative 60s ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.	0.999
A0A3Q0KFH7	A0A3Q0KV34	A0A3Q0KFH7	A0A3Q0KV34	Putative 60s ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	Putative 60s ribosomal protein L7a.	0.999
A0A3Q0KFH7	A0A3Q0KVH7	A0A3Q0KFH7	A0A3Q0KVH7	Putative 60s ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	Putative beta-1,4-galactosyltransferase.	0.999
A0A3Q0KFH7	A0A5K4F5A7	A0A3Q0KFH7	A0A5K4F5A7	Putative 60s ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	Uncharacterized protein.	0.999
A0A3Q0KFH7	A0A5K4F6K1	A0A3Q0KFH7	A0A5K4F6K1	Putative 60s ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	Uncharacterized protein.	0.999
A0A3Q0KFH7	A0A5K4F7C5	A0A3Q0KFH7	A0A5K4F7C5	Putative 60s ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	Uncharacterized protein.	0.999
A0A3Q0KFH7	A0A5K4FBY9	A0A3Q0KFH7	A0A5K4FBY9	Putative 60s ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	Uncharacterized protein.	0.999
A0A3Q0KFH7	A0A5K4FC15	A0A3Q0KFH7	A0A5K4FC15	Putative 60s ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	Uncharacterized protein.	0.999
A0A3Q0KFH7	A0A5K4FC25	A0A3Q0KFH7	A0A5K4FC25	Putative 60s ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	Uncharacterized protein.	0.999
A0A3Q0KFH7	c5016_g1_i1	A0A3Q0KFH7	A0A146MGD5	Putative 60s ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	Uncharacterized protein.	0.999
A0A3Q0KTS6	A0A3Q0KFH7	A0A3Q0KTS6	A0A3Q0KFH7	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.	Putative 60s ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	0.999
A0A3Q0KTS6	A0A3Q0KV34	A0A3Q0KTS6	A0A3Q0KV34	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.	Putative 60s ribosomal protein L7a.	0.999
A0A3Q0KTS6	A0A3Q0KVH7	A0A3Q0KTS6	A0A3Q0KVH7	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.	Putative beta-1,4-galactosyltransferase.	0.999
A0A3Q0KTS6	A0A5K4F5A7	A0A3Q0KTS6	A0A5K4F5A7	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.	Uncharacterized protein.	0.999
A0A3Q0KTS6	A0A5K4F6K1	A0A3Q0KTS6	A0A5K4F6K1	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.	Uncharacterized protein.	0.999
A0A3Q0KTS6	A0A5K4F7C5	A0A3Q0KTS6	A0A5K4F7C5	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.	Uncharacterized protein.	0.999
A0A3Q0KTS6	A0A5K4FBY9	A0A3Q0KTS6	A0A5K4FBY9	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.	Uncharacterized protein.	0.999
A0A3Q0KTS6	A0A5K4FC15	A0A3Q0KTS6	A0A5K4FC15	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.	Uncharacterized protein.	0.999
A0A3Q0KTS6	A0A5K4FC25	A0A3Q0KTS6	A0A5K4FC25	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.	Uncharacterized protein.	0.999
A0A3Q0KTS6	c5016_g1_i1	A0A3Q0KTS6	A0A146MGD5	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.	Uncharacterized protein.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.806

expected number of edges:

28

PPI enrichment p-value:

0.00127

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 104

1.54

3.31

2.45e-14

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 53

1.79

4.48

8.78e-15

GO:0019843

rRNA binding

7 of 42

1.73

3.12

3.68e-09

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.51

1.2

0.0063

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

11 of 61

1.77

4.86

1.07e-17

GO:0044391

Ribosomal subunit

2 of 13

1.7

0.92

0.0141

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33351813

(2020) Complete genome reveals genetic repertoire and potential metabolic strategies involved in lignin degradation by environmental ligninolytic Klebsiella variicola P1CD1.

6 of 29

1.83

3.22

9.46e-09

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:188

Ribosome

11 of 17

2.32

8.92

5.53e-22

CL:191

Ribosome

8 of 12

2.34

6.71

2.06e-15

CL:193

Small ribosomal subunit, and Ribosome

3 of 5

2.29

2.23

5.14e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gfo03010

Ribosome

11 of 53

1.83

5.3

2.53e-18

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

6 of 37

1.72

2.61

2.61e-07

GOCC:0043232

Intracellular non-membrane-bounded organelle

7 of 125

1.26

1.58

1.62e-06

GOCC:0043229

Intracellular organelle

10 of 380

0.93

1.04

2.92e-07

GOCC:0005622

Intracellular

11 of 1204

0.47

0.4

0.00031

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

11 of 56

1.81

5.09

8.08e-18

KW-0699

rRNA-binding

7 of 38

1.78

3.42

6.31e-10

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About