A0A3Q0KFT4 protein (Schistosoma mansoni) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

A0A3Q0KFT4

Tar DNA-binding protein, putative. (446 aa)

Predicted Functional Partners:

Smp_051300

0.903

Smp_103710

0.843

Smp_000240.2

0.727

Smp_113620.1

0.694

Smp_065580.3

0.683

Smp_068420

0.683

Smp_038680

0.659

A0A3Q0KUZ7

0.654

A0A5K4F676

0.654

A0A5K4F7K4

0.654

Your Current Organism:

Schistosoma mansoni

NCBI taxonomy Id: 6183
Other names: S. mansoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A3Q0KFT4	A0A3Q0KUZ7	A0A3Q0KFT4	A0A3Q0KUZ7	Tar DNA-binding protein, putative.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.654
A0A3Q0KFT4	A0A5K4F676	A0A3Q0KFT4	A0A5K4F676	Tar DNA-binding protein, putative.	Arginine/serine-rich splicing factor, putative.	0.654
A0A3Q0KFT4	A0A5K4F7K4	A0A3Q0KFT4	A0A5K4F7K4	Tar DNA-binding protein, putative.	Uncharacterized protein.	0.654
A0A3Q0KFT4	Smp_000240.2	A0A3Q0KFT4	G4LVS7	Tar DNA-binding protein, putative.	Fusion; RNA binding protein, putative.	0.727
A0A3Q0KFT4	Smp_038680	A0A3Q0KFT4	G4VI89	Tar DNA-binding protein, putative.	Small nuclear ribonucleoprotein G.	0.659
A0A3Q0KFT4	Smp_051300	A0A3Q0KFT4	G4LY23	Tar DNA-binding protein, putative.	Tar DNA-binding protein, putative.	0.903
A0A3Q0KFT4	Smp_065580.3	A0A3Q0KFT4	G4VAG9	Tar DNA-binding protein, putative.	Putative heterogeneous nuclear ribonucleoprotein k.	0.683
A0A3Q0KFT4	Smp_068420	A0A3Q0KFT4	Q4JHT3	Tar DNA-binding protein, putative.	Small nuclear ribonucleoprotein Sm D3.	0.683
A0A3Q0KFT4	Smp_103710	A0A3Q0KFT4	G4VRA7	Tar DNA-binding protein, putative.	Putative ubiquitin-conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.843
A0A3Q0KFT4	Smp_113620.1	A0A3Q0KFT4	G4VBT2	Tar DNA-binding protein, putative.	Putative serine/arginine rich splicing factor.	0.694
A0A3Q0KUZ7	A0A3Q0KFT4	A0A3Q0KUZ7	A0A3Q0KFT4	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	Tar DNA-binding protein, putative.	0.654
A0A3Q0KUZ7	A0A5K4F676	A0A3Q0KUZ7	A0A5K4F676	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	Arginine/serine-rich splicing factor, putative.	0.787
A0A3Q0KUZ7	A0A5K4F7K4	A0A3Q0KUZ7	A0A5K4F7K4	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	Uncharacterized protein.	0.787
A0A3Q0KUZ7	Smp_038680	A0A3Q0KUZ7	G4VI89	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	Small nuclear ribonucleoprotein G.	0.999
A0A3Q0KUZ7	Smp_051300	A0A3Q0KUZ7	G4LY23	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	Tar DNA-binding protein, putative.	0.654
A0A3Q0KUZ7	Smp_068420	A0A3Q0KUZ7	Q4JHT3	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	Small nuclear ribonucleoprotein Sm D3.	0.999
A0A5K4F676	A0A3Q0KFT4	A0A5K4F676	A0A3Q0KFT4	Arginine/serine-rich splicing factor, putative.	Tar DNA-binding protein, putative.	0.654
A0A5K4F676	A0A3Q0KUZ7	A0A5K4F676	A0A3Q0KUZ7	Arginine/serine-rich splicing factor, putative.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.787
A0A5K4F676	Smp_000240.2	A0A5K4F676	G4LVS7	Arginine/serine-rich splicing factor, putative.	Fusion; RNA binding protein, putative.	0.598
A0A5K4F676	Smp_038680	A0A5K4F676	G4VI89	Arginine/serine-rich splicing factor, putative.	Small nuclear ribonucleoprotein G.	0.779

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Network Stats

number of nodes:

7

number of edges:

21

average node degree:

6

avg. local clustering coefficient:

1

expected number of edges:

7

PPI enrichment p-value:

6.46e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016079

Synaptic vesicle exocytosis

3 of 14

2.89

2.81

3.61e-05

GO:0006887

Exocytosis

4 of 92

2.2

2.58

3.61e-05

GO:0048791

Calcium ion-regulated exocytosis of neurotransmitter

2 of 3

3.39

2.33

0.00024

GO:0016192

Vesicle-mediated transport

5 of 664

1.44

1.6

0.00011

GO:0140029

Exocytic process

2 of 30

2.39

1.33

0.0074

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019905

Syntaxin binding

3 of 37

2.47

2.2

0.00027

GO:0005484

SNAP receptor activity

2 of 40

2.26

0.88

0.0403

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098793

Presynapse

5 of 109

2.22

4.07

3.57e-08

GO:0008021

Synaptic vesicle

3 of 46

2.38

2.54

6.10e-05

GO:0070161

Anchoring junction

4 of 281

1.72

1.95

0.00011

GO:0030672

Synaptic vesicle membrane

2 of 21

2.54

1.71

0.0019

GO:0031201

SNARE complex

2 of 43

2.23

1.36

0.0061

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26734

Norepinephrine Neurotransmitter Release Cycle, and Rim-like

3 of 10

3.04

3.08

1.42e-05

CL:26699

Mixed, incl. Organic anion transporters, and Regulated exocytosis

4 of 94

2.19

2.78

1.42e-05

CL:6761

SNARE complex disassembly, and Other interleukin signaling

2 of 6

3.08

2.15

0.00044

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04130

SNARE interactions in vesicular transport

2 of 56

2.11

1.09

0.0167

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-449836

Other interleukin signaling

2 of 8

2.96

1.61

0.0031

MAP-181429

Serotonin Neurotransmitter Release Cycle

2 of 7

3.02

1.61

0.0031

MAP-212676

Dopamine Neurotransmitter Release Cycle

2 of 11

2.82

1.6

0.0031

MAP-210500

Glutamate Neurotransmitter Release Cycle

2 of 11

2.82

1.6

0.0031

MAP-181430

Norepinephrine Neurotransmitter Release Cycle

2 of 9

2.91

1.6

0.0031

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098793

Presynapse

5 of 68

2.43

4.8

4.28e-09

GOCC:0045202

Synapse

6 of 249

1.94

3.88

4.28e-09

GOCC:0030672

Synaptic vesicle membrane

3 of 19

2.76

3.26

5.98e-06

GOCC:0048788

Cytoskeleton of presynaptic active zone

2 of 5

3.16

2.42

0.00017

GOCC:0031410

Cytoplasmic vesicle

4 of 672

1.34

1.21

0.0012

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039032

Rim-like

2 of 3

3.39

1.61

0.0032

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