A0A3Q0KT73 protein (Schistosoma mansoni) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

A0A3Q0KT73

26S protease regulatory subunit, putative; Belongs to the AAA ATPase family. (433 aa)

Predicted Functional Partners:

Smp_052870

0.997

A0A3Q0KKA3

0.996

Smp_058650

0.996

Smp_012470

0.996

SmPOH

0.996

PSMD4_SCHMA

0.996

Smp_085310.1

0.995

A0A3Q0KE53

0.994

A0A3Q0KGQ2

0.994

A0A3Q0KHT5

0.993

Your Current Organism:

Schistosoma mansoni

NCBI taxonomy Id: 6183
Other names: S. mansoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A3Q0KE53	A0A3Q0KGQ2	A0A3Q0KE53	A0A3Q0KGQ2	Proteasome subunit alpha type.	26S proteasome subunit S9, putative.	0.999
A0A3Q0KE53	A0A3Q0KHT5	A0A3Q0KE53	A0A3Q0KHT5	Proteasome subunit alpha type.	Proteasome subunit beta.	0.999
A0A3Q0KE53	A0A3Q0KKA3	A0A3Q0KE53	A0A3Q0KKA3	Proteasome subunit alpha type.	Putative 26s protease regulatory subunit; Belongs to the AAA ATPase family.	0.999
A0A3Q0KE53	A0A3Q0KT73	A0A3Q0KE53	A0A3Q0KT73	Proteasome subunit alpha type.	26S protease regulatory subunit, putative; Belongs to the AAA ATPase family.	0.994
A0A3Q0KE53	PSMD4_SCHMA	A0A3Q0KE53	O17453	Proteasome subunit alpha type.	26S proteasome non-ATPase regulatory subunit 4; Binds and presumably selects ubiquitin-conjugates for destruction; Belongs to the proteasome subunit S5A family.	0.999
A0A3Q0KE53	SmPOH	A0A3Q0KE53	O16154	Proteasome subunit alpha type.	Pad1 homolog.	0.999
A0A3Q0KE53	Smp_012470	A0A3Q0KE53	G4V969	Proteasome subunit alpha type.	Putative 26s protease regulatory subunit; Belongs to the AAA ATPase family.	0.999
A0A3Q0KE53	Smp_052870	A0A3Q0KE53	G4VGE8	Proteasome subunit alpha type.	Putative 26s proteasome non-ATPase regulatory subunit.	0.999
A0A3Q0KE53	Smp_058650	A0A3Q0KE53	G4LX66	Proteasome subunit alpha type.	Proteasome regulatory subunit-related.	0.999
A0A3Q0KE53	Smp_085310.1	A0A3Q0KE53	G4LV41	Proteasome subunit alpha type.	26S proteasome regulatory subunit S3, putative.	0.998
A0A3Q0KGQ2	A0A3Q0KE53	A0A3Q0KGQ2	A0A3Q0KE53	26S proteasome subunit S9, putative.	Proteasome subunit alpha type.	0.999
A0A3Q0KGQ2	A0A3Q0KHT5	A0A3Q0KGQ2	A0A3Q0KHT5	26S proteasome subunit S9, putative.	Proteasome subunit beta.	0.999
A0A3Q0KGQ2	A0A3Q0KKA3	A0A3Q0KGQ2	A0A3Q0KKA3	26S proteasome subunit S9, putative.	Putative 26s protease regulatory subunit; Belongs to the AAA ATPase family.	0.999
A0A3Q0KGQ2	A0A3Q0KT73	A0A3Q0KGQ2	A0A3Q0KT73	26S proteasome subunit S9, putative.	26S protease regulatory subunit, putative; Belongs to the AAA ATPase family.	0.994
A0A3Q0KGQ2	PSMD4_SCHMA	A0A3Q0KGQ2	O17453	26S proteasome subunit S9, putative.	26S proteasome non-ATPase regulatory subunit 4; Binds and presumably selects ubiquitin-conjugates for destruction; Belongs to the proteasome subunit S5A family.	0.999
A0A3Q0KGQ2	SmPOH	A0A3Q0KGQ2	O16154	26S proteasome subunit S9, putative.	Pad1 homolog.	0.999
A0A3Q0KGQ2	Smp_012470	A0A3Q0KGQ2	G4V969	26S proteasome subunit S9, putative.	Putative 26s protease regulatory subunit; Belongs to the AAA ATPase family.	0.999
A0A3Q0KGQ2	Smp_052870	A0A3Q0KGQ2	G4VGE8	26S proteasome subunit S9, putative.	Putative 26s proteasome non-ATPase regulatory subunit.	0.999
A0A3Q0KGQ2	Smp_058650	A0A3Q0KGQ2	G4LX66	26S proteasome subunit S9, putative.	Proteasome regulatory subunit-related.	0.999
A0A3Q0KGQ2	Smp_085310.1	A0A3Q0KGQ2	G4LV41	26S proteasome subunit S9, putative.	26S proteasome regulatory subunit S3, putative.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

13

PPI enrichment p-value:

1.77e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006470

Protein dephosphorylation

8 of 403

2.28

6.06

4.16e-14

GO:0005983

Starch catabolic process

4 of 70

2.74

3.7

1.24e-07

GO:0046838

Phosphorylated carbohydrate dephosphorylation

4 of 85

2.65

3.61

1.60e-07

GO:0007623

Circadian rhythm

3 of 400

1.86

1.33

0.0021

GO:0006796

Phosphate-containing compound metabolic process

10 of 8535

1.05

1.27

1.60e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008138

Protein tyrosine/serine/threonine phosphatase activity

5 of 70

2.83

5.41

6.79e-11

GO:0004721

Phosphoprotein phosphatase activity

8 of 558

2.14

5.38

3.00e-13

GO:2001066

Amylopectin binding

3 of 6

3.68

4.11

3.92e-08

GO:0019203

Carbohydrate phosphatase activity

4 of 86

2.65

3.78

7.54e-08

GO:2001070

Starch binding

3 of 45

2.8

2.91

4.48e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009570

Chloroplast stroma

4 of 1452

1.42

0.99

0.0052

GO:0110165

Cellular anatomical entity

10 of 19699

0.69

0.57

0.00045

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:25640

Energy dependent regulation of mTOR by LKB1-AMPK, and CaM pathway

5 of 83

2.76

4.57

2.60e-09

CL:25743

Mixed, incl. AMP binding, and Laforin-like, dual specificity phosphatase domain

4 of 29

3.12

4.53

5.11e-09

CL:40594

Mixed, incl. Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response, and bZIP transcription factor RISBZ3/4/5

3 of 13

3.34

3.45

5.66e-07

CL:25745

Mixed, incl. Laforin-like, dual specificity phosphatase domain, and AMP binding

3 of 17

3.23

3.29

1.07e-06

CL:40595

Mixed, incl. Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response, and bZIP transcription factor RISBZ3/4/5

2 of 8

3.38

1.96

0.00029

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-162582

Signal Transduction

5 of 4506

1.03

0.52

0.0474

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043036

Starch grain

6 of 23

3.4

8.59

1.95e-16

GOCC:0005952

cAMP-dependent protein kinase complex

3 of 12

3.38

3.59

3.23e-07

GOCC:0009501

Amyloplast

3 of 97

2.47

2.2

7.61e-05

GOCC:0110165

Cellular anatomical entity

8 of 8339

0.96

0.92

8.72e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0904

Protein phosphatase

3 of 187

2.19

1.8

0.00034

KW-0460

Magnesium

3 of 742

1.59

0.95

0.0100

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16561

Glycogen recognition site of AMP-activated protein kinase

6 of 26

3.34

8.26

7.32e-16

PF00782

Dual specificity phosphatase, catalytic domain

6 of 33

3.24

8.08

1.32e-15

PF00069

Protein kinase domain

4 of 474

1.91

1.85

0.00015

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045204

Laforin-like, dual specificity phosphatase domain

6 of 9

3.8

9.37

1.17e-17

IPR032640

AMP-activated protein kinase, glycogen-binding domain

6 of 26

3.34

8.18

1.06e-15

IPR000340

Dual specificity phosphatase, catalytic domain

6 of 53

3.03

7.22

3.50e-14

IPR020422

Dual specificity protein phosphatase domain

6 of 57

3.0

7.17

3.95e-14

IPR000387

Tyrosine-specific protein phosphatases domain

6 of 67

2.93

6.96

7.92e-14

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00332

Serine/threonine phosphatases, family 2C, catalytic domain

3 of 40

2.86

2.81

6.91e-06

SM00100

Cyclic nucleotide-monophosphate binding domain

3 of 91

2.5

2.36

3.74e-05

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