A0A5K4F0L3 protein (Schistosoma mansoni) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A5K4F0L3

Uncharacterized protein. (390 aa)

Predicted Functional Partners:

A0A5K4EZN8

0.823

A0A5K4FBD9

0.783

A0A5K4FCQ9

0.783

A0A3Q0KSB3

0.587

A0A3Q0KBK2

0.551

Smp_174320

0.550

A0A3Q0KGD6

0.518

A0A3Q0KKU5

0.518

A0A3Q0KPN7

0.518

A0A3Q0KU10

0.518

Your Current Organism:

Schistosoma mansoni

NCBI taxonomy Id: 6183
Other names: S. mansoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A3Q0KBK2	A0A5K4F0L3	A0A3Q0KBK2	A0A5K4F0L3	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Uncharacterized protein.	0.551
A0A3Q0KGD6	A0A5K4F0L3	A0A3Q0KGD6	A0A5K4F0L3	Protein kinase.	Uncharacterized protein.	0.518
A0A3Q0KGD6	A0A5K4FBD9	A0A3Q0KGD6	A0A5K4FBD9	Protein kinase.	Uncharacterized protein.	0.540
A0A3Q0KGD6	A0A5K4FCQ9	A0A3Q0KGD6	A0A5K4FCQ9	Protein kinase.	Uncharacterized protein.	0.540
A0A3Q0KKU5	A0A5K4F0L3	A0A3Q0KKU5	A0A5K4F0L3	Tyrosine-protein kinase.	Uncharacterized protein.	0.518
A0A3Q0KKU5	A0A5K4FBD9	A0A3Q0KKU5	A0A5K4FBD9	Tyrosine-protein kinase.	Uncharacterized protein.	0.540
A0A3Q0KKU5	A0A5K4FCQ9	A0A3Q0KKU5	A0A5K4FCQ9	Tyrosine-protein kinase.	Uncharacterized protein.	0.540
A0A3Q0KPN7	A0A5K4F0L3	A0A3Q0KPN7	A0A5K4F0L3	Tyrosine-protein kinase.	Uncharacterized protein.	0.518
A0A3Q0KPN7	A0A5K4FBD9	A0A3Q0KPN7	A0A5K4FBD9	Tyrosine-protein kinase.	Uncharacterized protein.	0.540
A0A3Q0KPN7	A0A5K4FCQ9	A0A3Q0KPN7	A0A5K4FCQ9	Tyrosine-protein kinase.	Uncharacterized protein.	0.540
A0A3Q0KSB3	A0A5K4F0L3	A0A3Q0KSB3	A0A5K4F0L3	Methionyl-tRNA formyltransferase, putative.	Uncharacterized protein.	0.587
A0A3Q0KU10	A0A5K4F0L3	A0A3Q0KU10	A0A5K4F0L3	Serine/threonine kinase.	Uncharacterized protein.	0.518
A0A3Q0KU10	A0A5K4FBD9	A0A3Q0KU10	A0A5K4FBD9	Serine/threonine kinase.	Uncharacterized protein.	0.540
A0A3Q0KU10	A0A5K4FCQ9	A0A3Q0KU10	A0A5K4FCQ9	Serine/threonine kinase.	Uncharacterized protein.	0.540
A0A5K4EZN8	A0A5K4F0L3	A0A5K4EZN8	A0A5K4F0L3	Uncharacterized protein.	Uncharacterized protein.	0.823
A0A5K4F0L3	A0A3Q0KBK2	A0A5K4F0L3	A0A3Q0KBK2	Uncharacterized protein.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.551
A0A5K4F0L3	A0A3Q0KGD6	A0A5K4F0L3	A0A3Q0KGD6	Uncharacterized protein.	Protein kinase.	0.518
A0A5K4F0L3	A0A3Q0KKU5	A0A5K4F0L3	A0A3Q0KKU5	Uncharacterized protein.	Tyrosine-protein kinase.	0.518
A0A5K4F0L3	A0A3Q0KPN7	A0A5K4F0L3	A0A3Q0KPN7	Uncharacterized protein.	Tyrosine-protein kinase.	0.518
A0A5K4F0L3	A0A3Q0KSB3	A0A5K4F0L3	A0A3Q0KSB3	Uncharacterized protein.	Methionyl-tRNA formyltransferase, putative.	0.587

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.849

expected number of edges:

46

PPI enrichment p-value:

0.999

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006635

Fatty acid beta-oxidation

7 of 45

2.32

5.45

2.75e-12

GO:0009062

Fatty acid catabolic process

8 of 69

2.19

5.42

5.90e-13

GO:0046395

Carboxylic acid catabolic process

9 of 173

1.84

4.27

9.38e-13

GO:0033540

Fatty acid beta-oxidation using acyl-CoA oxidase

3 of 5

2.9

2.81

7.18e-06

GO:0032787

Monocarboxylic acid metabolic process

9 of 364

1.52

2.77

1.50e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003997

acyl-CoA oxidase activity

3 of 6

2.82

2.28

6.92e-05

GO:0003988

acetyl-CoA C-acyltransferase activity

3 of 7

2.76

2.27

6.92e-05

GO:0050633

acetyl-CoA C-myristoyltransferase activity

2 of 4

2.82

1.36

0.0034

GO:0050218

propionate-CoA ligase activity

2 of 4

2.82

1.36

0.0034

GO:0003987

acetate-CoA ligase activity

2 of 5

2.73

1.36

0.0034

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005777

Peroxisome

3 of 106

1.58

0.69

0.0412

GO:0005759

Mitochondrial matrix

4 of 247

1.33

0.68

0.0329

GO:0005739

Mitochondrion

6 of 1111

0.86

0.47

0.0412

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37893980

(2023) The Identification of Functional Genes Affecting Fat-Related Meat Traits in Meat-Type Pigeons Using Double-Digest Restriction-Associated DNA Sequencing and Molecular Docking Analysis.

4 of 16

2.52

3.1

1.31e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7145

Fatty acid degradation, and Valine catabolic process

10 of 23

2.76

11.37

9.07e-24

CL:7142

Fatty acid beta-oxidation, and Branched-chain amino acid catabolic process

11 of 38

2.59

11.21

5.86e-25

CL:7147

Mixed, incl. Beta oxidation of octanoyl-CoA to hexanoyl-CoA, and Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily

9 of 17

2.85

10.74

7.45e-22

CL:7168

Beta oxidation of butanoyl-CoA to acetyl-CoA, and Thymine metabolic process

5 of 5

3.12

6.11

5.73e-12

CL:7151

Mixed, incl. Fatty acid beta-oxidation multienzyme complex, and acetyl-CoA hydrolase activity

3 of 6

2.82

2.81

6.73e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

clv00640

Propanoate metabolism

7 of 29

2.51

6.75

1.61e-14

clv00071

Fatty acid degradation

6 of 33

2.38

5.36

9.16e-12

clv00280

Valine, leucine and isoleucine degradation

6 of 41

2.29

5.06

2.01e-11

clv01212

Fatty acid metabolism

6 of 51

2.19

4.73

5.07e-11

clv01200

Carbon metabolism

5 of 98

1.83

2.83

1.95e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-77289

Mitochondrial Fatty Acid Beta-Oxidation

5 of 37

2.25

3.57

5.77e-08

MAP-8978868

Fatty acid metabolism

8 of 185

1.76

3.48

2.10e-10

MAP-77350

Beta oxidation of hexanoyl-CoA to butanoyl-CoA

3 of 6

2.82

2.75

8.80e-06

MAP-77348

Beta oxidation of octanoyl-CoA to hexanoyl-CoA

3 of 6

2.82

2.75

8.80e-06

MAP-77310

Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA

3 of 6

2.82

2.75

8.80e-06

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001630

Right ventricle

3 of 18

2.35

2.8

3.76e-06

BTO:0001489

Whole body

11 of 9568

0.18

0.21

0.0170

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

3 of 93

1.63

0.83

0.0213

GOCC:0005739

Mitochondrion

6 of 701

1.06

0.78

0.0047

GOCC:0005737

Cytoplasm

11 of 4626

0.5

0.38

0.0047

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0012

Acyltransferase

3 of 77

1.71

1.03

0.0080

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00108

Thiolase, N-terminal domain

3 of 4

3.0

2.58

2.03e-05

PF14749

Acyl-coenzyme A oxidase N-terminal

2 of 3

2.95

1.29

0.0047

PF02803

Thiolase, C-terminal domain

2 of 5

2.73

1.2

0.0066

PF13193

AMP-binding enzyme C-terminal domain

2 of 11

2.38

0.95

0.0183

PF02770

Acyl-CoA dehydrogenase, middle domain

2 of 11

2.38

0.95

0.0183

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020610

Thiolase, active site

3 of 5

2.9

2.2

0.00010

IPR020617

Thiolase, C-terminal

3 of 6

2.82

2.19

0.00010

IPR020616

Thiolase, N-terminal

3 of 6

2.82

2.19

0.00010

IPR020613

Thiolase, conserved site

3 of 6

2.82

2.19

0.00010

IPR002155

Thiolase

3 of 6

2.82

2.19

0.00010

(more ...)

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