STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
I0B503_SCHMAS-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (299 aa)    
Predicted Functional Partners:
Smp_171620
S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
  
 
 
0.902
Smp_054360
Putative adenine phosphoribosyltransferase.
 
 
 0.799
Smp_082430
Putative uridine phosphorylase.
  
 
 0.754
A0A3Q0KC36
Putative adenosine kinase.
  
 0.746
Smp_151260
Putative adenine phosphoribosyltransferase.
  
 
 0.744
Smp_054410
Putative adenine phosphoribosyltransferase.
  
 
 0.744
A0A3Q0KC34
Putative adenosine kinase.
   
 0.741
A0A3Q0KEH2
Putative adenosine deaminase.
  
 
 0.636
Smp_012930
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
  
 
 0.605
Smp_017230
Nicotinate phosphoribosyltransferase related pre-B cell enhancing factor.
     
 0.605
Your Current Organism:
Schistosoma mansoni
NCBI taxonomy Id: 6183
Other names: S. mansoni
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