| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NEDD8 | RANGAP1 | ENSNLEP00000027144 | ENSNLEP00000018766 | NEDD8 ubiquitin like modifier. | Ran GTPase activating protein 1. | 0.486 |
| NEDD8 | SENP1 | ENSNLEP00000027144 | ENSNLEP00000021737 | NEDD8 ubiquitin like modifier. | SUMO specific peptidase 1. | 0.408 |
| NEDD8 | SUMO2 | ENSNLEP00000027144 | ENSNLEP00000040203 | NEDD8 ubiquitin like modifier. | Small ubiquitin-related modifier. | 0.763 |
| NEDD8 | UBA2 | ENSNLEP00000027144 | ENSNLEP00000013124 | NEDD8 ubiquitin like modifier. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.595 |
| NEDD8 | UBE2I | ENSNLEP00000027144 | ENSNLEP00000010420 | NEDD8 ubiquitin like modifier. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.593 |
| PIAS1 | RANBP2 | ENSNLEP00000031601 | ENSNLEP00000009128 | Protein inhibitor of activated STAT 1. | RAN binding protein 2. | 0.659 |
| PIAS1 | SENP1 | ENSNLEP00000031601 | ENSNLEP00000021737 | Protein inhibitor of activated STAT 1. | SUMO specific peptidase 1. | 0.822 |
| PIAS1 | SENP2 | ENSNLEP00000031601 | ENSNLEP00000007912 | Protein inhibitor of activated STAT 1. | SUMO specific peptidase 2. | 0.654 |
| PIAS1 | SUMO2 | ENSNLEP00000031601 | ENSNLEP00000040203 | Protein inhibitor of activated STAT 1. | Small ubiquitin-related modifier. | 0.764 |
| PIAS1 | UBA2 | ENSNLEP00000031601 | ENSNLEP00000013124 | Protein inhibitor of activated STAT 1. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.509 |
| PIAS1 | UBE2I | ENSNLEP00000031601 | ENSNLEP00000010420 | Protein inhibitor of activated STAT 1. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.993 |
| PRKCZ | SUMO2 | ENSNLEP00000000211 | ENSNLEP00000040203 | Protein kinase C zeta. | Small ubiquitin-related modifier. | 0.902 |
| PRKCZ | TP53 | ENSNLEP00000000211 | ENSNLEP00000011861 | Protein kinase C zeta. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.900 |
| RANBP2 | PIAS1 | ENSNLEP00000009128 | ENSNLEP00000031601 | RAN binding protein 2. | Protein inhibitor of activated STAT 1. | 0.659 |
| RANBP2 | RANGAP1 | ENSNLEP00000009128 | ENSNLEP00000018766 | RAN binding protein 2. | Ran GTPase activating protein 1. | 0.997 |
| RANBP2 | SENP1 | ENSNLEP00000009128 | ENSNLEP00000021737 | RAN binding protein 2. | SUMO specific peptidase 1. | 0.506 |
| RANBP2 | SENP2 | ENSNLEP00000009128 | ENSNLEP00000007912 | RAN binding protein 2. | SUMO specific peptidase 2. | 0.401 |
| RANBP2 | SUMO2 | ENSNLEP00000009128 | ENSNLEP00000040203 | RAN binding protein 2. | Small ubiquitin-related modifier. | 0.776 |
| RANBP2 | UBA2 | ENSNLEP00000009128 | ENSNLEP00000013124 | RAN binding protein 2. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.545 |
| RANBP2 | UBE2I | ENSNLEP00000009128 | ENSNLEP00000010420 | RAN binding protein 2. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.998 |
