Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PTPN4Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (926 aa)    
Predicted Functional Partners:
MAPK12
Mitogen-activated protein kinase.
    
 0.870
GRIN2A
Glutamate ionotropic receptor NMDA type subunit 2A.
    
 
 0.752
MAPK13
Mitogen-activated protein kinase.
    
 0.615
MAPK14
Mitogen-activated protein kinase.
    
 0.615
MAPK11
Mitogen-activated protein kinase.
    
 0.615
PTS
6-pyruvoyl tetrahydrobiopterin synthase.
    
 
 0.599
ADAM17
ADAM metallopeptidase domain 17.
   
 0.560
TMEM185B
Uncharacterized protein.
    
 
 0.543
TICAM2
Toll like receptor adaptor molecule 2.
     
  0.538
TICAM1
TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.
     
  0.538
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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