| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BLM | EME1 | ENSNLEP00000014738 | ENSNLEP00000011035 | BLM RecQ like helicase. | Essential meiotic structure-specific endonuclease 1. | 0.819 |
| BLM | ERCC1 | ENSNLEP00000014738 | ENSNLEP00000002490 | BLM RecQ like helicase. | Uncharacterized protein. | 0.630 |
| BLM | MUS81 | ENSNLEP00000014738 | ENSNLEP00000007117 | BLM RecQ like helicase. | MUS81 structure-specific endonuclease subunit. | 0.936 |
| BLM | NARS1 | ENSNLEP00000014738 | ENSNLEP00000009876 | BLM RecQ like helicase. | Asparaginyl-tRNA synthetase. | 0.592 |
| BLM | RAD50 | ENSNLEP00000014738 | ENSNLEP00000015512 | BLM RecQ like helicase. | Zinc-hook domain-containing protein. | 0.953 |
| BLM | RAD51 | ENSNLEP00000014738 | ENSNLEP00000037495 | BLM RecQ like helicase. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.988 |
| BLM | SLX1A | ENSNLEP00000014738 | ENSNLEP00000001190 | BLM RecQ like helicase. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. | 0.933 |
| BLM | SLX4 | ENSNLEP00000014738 | ENSNLEP00000011796 | BLM RecQ like helicase. | SLX4 structure-specific endonuclease subunit. | 0.670 |
| BLM | TOP3A | ENSNLEP00000014738 | ENSNLEP00000031941 | BLM RecQ like helicase. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.999 |
| BLM | WRN | ENSNLEP00000014738 | ENSNLEP00000045895 | BLM RecQ like helicase. | WRN RecQ like helicase. | 0.610 |
| EME1 | BLM | ENSNLEP00000011035 | ENSNLEP00000014738 | Essential meiotic structure-specific endonuclease 1. | BLM RecQ like helicase. | 0.819 |
| EME1 | ERCC1 | ENSNLEP00000011035 | ENSNLEP00000002490 | Essential meiotic structure-specific endonuclease 1. | Uncharacterized protein. | 0.865 |
| EME1 | MUS81 | ENSNLEP00000011035 | ENSNLEP00000007117 | Essential meiotic structure-specific endonuclease 1. | MUS81 structure-specific endonuclease subunit. | 0.999 |
| EME1 | NARS1 | ENSNLEP00000011035 | ENSNLEP00000009876 | Essential meiotic structure-specific endonuclease 1. | Asparaginyl-tRNA synthetase. | 0.826 |
| EME1 | RAD50 | ENSNLEP00000011035 | ENSNLEP00000015512 | Essential meiotic structure-specific endonuclease 1. | Zinc-hook domain-containing protein. | 0.839 |
| EME1 | RAD51 | ENSNLEP00000011035 | ENSNLEP00000037495 | Essential meiotic structure-specific endonuclease 1. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.887 |
| EME1 | SLX1A | ENSNLEP00000011035 | ENSNLEP00000001190 | Essential meiotic structure-specific endonuclease 1. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. | 0.902 |
| EME1 | SLX4 | ENSNLEP00000011035 | ENSNLEP00000011796 | Essential meiotic structure-specific endonuclease 1. | SLX4 structure-specific endonuclease subunit. | 0.988 |
| EME1 | TOP3A | ENSNLEP00000011035 | ENSNLEP00000031941 | Essential meiotic structure-specific endonuclease 1. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.773 |
| EME1 | WRN | ENSNLEP00000011035 | ENSNLEP00000045895 | Essential meiotic structure-specific endonuclease 1. | WRN RecQ like helicase. | 0.800 |
