Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
LRRK1Leucine rich repeat kinase 1. (1816 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor bound protein 2.
    
 0.847
BAG5
BCL2 associated athanogene 5.
    
   0.752
ABL1
Tyrosine-protein kinase.
   
  0.744
SHC1
SHC adaptor protein 1.
    
  0.651
ENSNLEP00000039370
SH2 domain-containing protein.
    
  0.651
ENSNLEP00000046563
Uncharacterized protein.
    
  0.651
YWHAB
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.
    
 0.639
EGFR
Receptor protein-tyrosine kinase.
    
 0.627
GSK3A
Glycogen synthase kinase 3 alpha.
    
 0.620
LRRK2
Leucine rich repeat kinase 2.
    
 0.618
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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