Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ABCA7Uncharacterized protein. (1829 aa)    
Predicted Functional Partners:
SORL1
Sortilin related receptor 1.
    
 
 0.681
NR1H4
Nuclear receptor subfamily 1 group H member 4.
    
 0.675
PSEN2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
      
 0.647
DBN1
Drebrin 1.
   
  
 0.647
SLC10A1
Solute carrier family 10 member 1.
      
 0.644
APOC4
Uncharacterized protein.
   
  
 0.643
EPHA1
EPH receptor A1.
   
  
 0.630
CLU
Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.
    
 
 0.621
SLCO1A2
Solute carrier organic anion transporter family member.
      
 0.617
PICALM
Phosphatidylinositol binding clathrin assembly protein.
      
 0.599
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (12%) [HD]