Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MPHOSPH8M-phase phosphoprotein 8. (860 aa)    
Predicted Functional Partners:
DNMT3A
DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
   
 0.929
TASOR
Transcription activation suppressor.
    
 0.884
SIRT1
Sirtuin 1.
    
 0.878
SIRT5
NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...]
    
 0.878
PPHLN1
Periphilin 1.
    
 0.827
SETDB1
SET domain bifurcated histone lysine methyltransferase 1.
    
 0.806
IP6K1
Kinase; Belongs to the inositol phosphokinase (IPK) family.
    
 0.767
IP6K3
Kinase; Belongs to the inositol phosphokinase (IPK) family.
    
 0.767
IPMK
Kinase; Belongs to the inositol phosphokinase (IPK) family.
    
 0.767
IP6K2
Kinase; Belongs to the inositol phosphokinase (IPK) family.
    
 0.767
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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