Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (233 aa)    
Predicted Functional Partners:
GPX2
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
  
 
0.977
GSR
Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
  
 0.975
GPX1
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
  
 
0.957
ALOX15
Arachidonate 15-lipoxygenase.
     
 0.944
PRDX6
Peroxiredoxin 6.
   
 0.935
CHAC1
Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.
     
 0.928
GPX5
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
  
  
0.928
GPX3
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
  
  
0.927
GPX8
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
  
 
0.926
ALOX5
Arachidonate 5-lipoxygenase.
    
 0.924
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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