RNF168 protein (Nomascus leucogenys) - STRING interaction network

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RNF168

E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)

Predicted Functional Partners:

TP53BP1

0.989

H2AX

0.968

H2AC20

0.940

UBE2N

0.936

UBE2V2

0.922

BRCA1

0.914

ENSNLEP00000034619

0.895

ENSNLEP00000041707

0.876

ENSNLEP00000042204

0.876

LOC100595614

0.859

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	ENSNLEP00000034619	ENSNLEP00000042201	ENSNLEP00000034619	BRCA1 DNA repair associated.	Ubiquitin-like domain-containing protein.	0.845
BRCA1	ENSNLEP00000041707	ENSNLEP00000042201	ENSNLEP00000041707	BRCA1 DNA repair associated.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.852
BRCA1	ENSNLEP00000042204	ENSNLEP00000042201	ENSNLEP00000042204	BRCA1 DNA repair associated.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.852
BRCA1	H2AC20	ENSNLEP00000042201	ENSNLEP00000022186	BRCA1 DNA repair associated.	Histone H2A; Belongs to the histone H2A family.	0.901
BRCA1	H2AX	ENSNLEP00000042201	ENSNLEP00000038777	BRCA1 DNA repair associated.	Histone H2A; Belongs to the histone H2A family.	0.980
BRCA1	LOC100595614	ENSNLEP00000042201	ENSNLEP00000034056	BRCA1 DNA repair associated.	Histone H2A; Belongs to the histone H2A family.	0.856
BRCA1	RNF168	ENSNLEP00000042201	ENSNLEP00000001828	BRCA1 DNA repair associated.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	0.914
BRCA1	TP53BP1	ENSNLEP00000042201	ENSNLEP00000006165	BRCA1 DNA repair associated.	Tumor protein p53 binding protein 1.	0.992
BRCA1	UBE2N	ENSNLEP00000042201	ENSNLEP00000006897	BRCA1 DNA repair associated.	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.852
BRCA1	UBE2V2	ENSNLEP00000042201	ENSNLEP00000035256	BRCA1 DNA repair associated.	Ubiquitin conjugating enzyme E2 V2.	0.403
ENSNLEP00000034619	BRCA1	ENSNLEP00000034619	ENSNLEP00000042201	Ubiquitin-like domain-containing protein.	BRCA1 DNA repair associated.	0.845
ENSNLEP00000034619	ENSNLEP00000041707	ENSNLEP00000034619	ENSNLEP00000041707	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.879
ENSNLEP00000034619	ENSNLEP00000042204	ENSNLEP00000034619	ENSNLEP00000042204	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.879
ENSNLEP00000034619	H2AC20	ENSNLEP00000034619	ENSNLEP00000022186	Ubiquitin-like domain-containing protein.	Histone H2A; Belongs to the histone H2A family.	0.726
ENSNLEP00000034619	H2AX	ENSNLEP00000034619	ENSNLEP00000038777	Ubiquitin-like domain-containing protein.	Histone H2A; Belongs to the histone H2A family.	0.551
ENSNLEP00000034619	LOC100595614	ENSNLEP00000034619	ENSNLEP00000034056	Ubiquitin-like domain-containing protein.	Histone H2A; Belongs to the histone H2A family.	0.569
ENSNLEP00000034619	RNF168	ENSNLEP00000034619	ENSNLEP00000001828	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	0.895
ENSNLEP00000034619	TP53BP1	ENSNLEP00000034619	ENSNLEP00000006165	Ubiquitin-like domain-containing protein.	Tumor protein p53 binding protein 1.	0.577
ENSNLEP00000034619	UBE2N	ENSNLEP00000034619	ENSNLEP00000006897	Ubiquitin-like domain-containing protein.	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.879
ENSNLEP00000034619	UBE2V2	ENSNLEP00000034619	ENSNLEP00000035256	Ubiquitin-like domain-containing protein.	Ubiquitin conjugating enzyme E2 V2.	0.944

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