Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
WWP1E3 ubiquitin-protein ligase. (922 aa)    
Predicted Functional Partners:
ITCH
E3 ubiquitin-protein ligase.
   
  0.867
ARRDC1
Arrestin_C domain-containing protein.
    
 
 0.843
DVL2
Dishevelled segment polarity protein 2.
    
 0.843
EGFR
Receptor protein-tyrosine kinase.
    
 0.839
DTX1
Deltex E3 ubiquitin ligase 1.
    
 0.827
SMAD7
Mothers against decapentaplegic homolog.
    
 0.821
WBP2
WW domain binding protein 2.
    
 
 0.807
SMAD3
Mothers against decapentaplegic homolog.
    
 0.805
SPART
Spartin.
    
 
 0.800
RNF11
RING-type domain-containing protein.
    
 0.794
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.