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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GSDMDUncharacterized protein. (494 aa)    
Predicted Functional Partners:
CASP1
Caspase 1; Belongs to the peptidase C14A family.
   
 0.987
CASP4
Caspase 4; Belongs to the peptidase C14A family.
   
 0.980
CASP5
Caspase 5; Belongs to the peptidase C14A family.
   
 0.947
CASP3
Caspase 3; Belongs to the peptidase C14A family.
    
 0.834
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
    
 0.833
CASP8
Caspase 8; Belongs to the peptidase C14A family.
   
 0.786
ELANE
Elastase, neutrophil expressed; Belongs to the peptidase S1 family.
     
 0.749
IL1A
Interleukin-1; Belongs to the IL-1 family.
    
 0.742
IRF1
Interferon regulatory factor.
   
 
 0.701
CASP7
Caspase 7; Belongs to the peptidase C14A family.
    
 0.689
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.