LIG3 protein (Nomascus leucogenys) - STRING interaction network

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Score

LIG3

DNA ligase. (941 aa)

Predicted Functional Partners:

XRCC1

0.999

POLB

0.989

PNKP

0.965

TDP1

0.938

XRCC5

0.927

XRCC6

0.919

LOC100580673

0.919

APLF

0.914

APEX1

0.888

PARP1

0.879

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APEX1	LIG3	ENSNLEP00000013259	ENSNLEP00000035608	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA ligase.	0.888
APEX1	PARP1	ENSNLEP00000013259	ENSNLEP00000016881	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.871
APEX1	PNKP	ENSNLEP00000013259	ENSNLEP00000033964	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	FHA_2 domain-containing protein.	0.766
APEX1	POLB	ENSNLEP00000013259	ENSNLEP00000015641	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.982
APEX1	TDP1	ENSNLEP00000013259	ENSNLEP00000040013	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Tyrosyl-DNA phosphodiesterase 1.	0.719
APEX1	XRCC1	ENSNLEP00000013259	ENSNLEP00000001912	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	X-ray repair cross complementing 1.	0.958
APEX1	XRCC5	ENSNLEP00000013259	ENSNLEP00000008862	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.546
APLF	LIG3	ENSNLEP00000012214	ENSNLEP00000035608	Aprataxin and PNKP like factor.	DNA ligase.	0.914
APLF	LOC100580673	ENSNLEP00000012214	ENSNLEP00000043734	Aprataxin and PNKP like factor.	Ku domain-containing protein.	0.938
APLF	PARP1	ENSNLEP00000012214	ENSNLEP00000016881	Aprataxin and PNKP like factor.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.892
APLF	PNKP	ENSNLEP00000012214	ENSNLEP00000033964	Aprataxin and PNKP like factor.	FHA_2 domain-containing protein.	0.663
APLF	POLB	ENSNLEP00000012214	ENSNLEP00000015641	Aprataxin and PNKP like factor.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.883
APLF	TDP1	ENSNLEP00000012214	ENSNLEP00000040013	Aprataxin and PNKP like factor.	Tyrosyl-DNA phosphodiesterase 1.	0.833
APLF	XRCC1	ENSNLEP00000012214	ENSNLEP00000001912	Aprataxin and PNKP like factor.	X-ray repair cross complementing 1.	0.978
APLF	XRCC5	ENSNLEP00000012214	ENSNLEP00000008862	Aprataxin and PNKP like factor.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.979
APLF	XRCC6	ENSNLEP00000012214	ENSNLEP00000018935	Aprataxin and PNKP like factor.	X-ray repair cross complementing 6.	0.938
LIG3	APEX1	ENSNLEP00000035608	ENSNLEP00000013259	DNA ligase.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.888
LIG3	APLF	ENSNLEP00000035608	ENSNLEP00000012214	DNA ligase.	Aprataxin and PNKP like factor.	0.914
LIG3	LOC100580673	ENSNLEP00000035608	ENSNLEP00000043734	DNA ligase.	Ku domain-containing protein.	0.919
LIG3	PARP1	ENSNLEP00000035608	ENSNLEP00000016881	DNA ligase.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.879

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